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C2081

Anti-α-Catenin antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-α-Catenin, Alpha Catenin Antibody, Alpha Catenin Antibody - Anti-α-Catenin antibody produced in rabbit

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Size/SKUAvailabilityPrice
0.2 mL

Available to ship TODAYfromMILWAUKEE

$445.00

About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, DB, IF, IHC (f), WB
Citations:
90

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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

mol wt

antigen ~102 kDa

contains

15 mM sodium azide

species reactivity

several mammalian species

technique(s)

dot blot: suitable using α-catenin peptide amino acids 890-901 conjugated to BSA, immunohistochemistry (frozen sections): 1:2,000 using bovine kidney sections, indirect immunofluorescence: 1:2,000 using cultured MDBK cells, microarray: suitable, western blot: 1:4,000 using cultured MDBK cells extract

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CTNNA1(1495)
mouse ... Ctnna1(12385)
rat ... Ctnna1(307505)

General description

Catenin are distinct peripheral cytosolic proteins, α, β, and γ -catenin (102 kDa, 94 kDa and 86 kDa, respectively) are found in varying abundance in many developing and adult tissues. Within its conserved regions, α-catenin shows 30% identity to vinculin, a protein found mainly in focal cell-cell and cell substrate adhesions.

Immunogen

synthetic peptide corresponding to the C-terminal region (amino acids 890-901) of human/mouse α-catenin conjugated to KLH.

Application

Anti-α-Catenin antibody has been used:
  • in dot blot immunoassay
  • in immunoblotting
  • in immunofluorescence
  • in western blotting
  • in immunoprecipitation
  • in immunofluorescence staining
  • in coimmunoprecipitation

Biochem/physiol Actions

Catenins bind, directly or indirectly, to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Cadherins are transmembrane cell surface glycoprotein molecules that mediate calcium-dependent intercellular interactions and are important for tissue morphogenesis. Catenins link E-cadherin to other integral membrane proteins such as Na+ /K+ -ATPase, or to cytoplasmic proteins such as fodrin, ankyrin, sarcoma (Src) and Yes kinases and are modulated by Wnt-1 protooncogene. They are considered good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. α-Catenin appears to be capable of interacting with N-cadherin and P-cadherin. Absence of α-catenin is found in certain tumor cell lines. Frequent reduction of α-catenin levels in human carcinomas of the esophagus, stomach and colon is also reported. Prostate cancer development appears to be correlated with α-catenin gene deletions.
Does not cross-react with β-catenin or γ-catenin (plakoglobin).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-α-Catenin antibody produced in rabbit whole antiserum

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Anti-Alpha-Catenin Antibody, clone 1G5 clone 1G5, from mouse

Sigma-Aldrich

MABT1508

Anti-Alpha-Catenin Antibody, clone 1G5

description

whole antiserum

description

clone 15B8, ascites fluid

description

clone EA-53, purified from hybridoma cell culture

description

clone 1G5, from mouse

biological source

rabbit

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

whole antiserum

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

purified antibody

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

indirect immunofluorescence: 1:2,000 using cultured MDBK cells, dot blot: suitable using α-catenin peptide amino acids 890-901 conjugated to BSA, microarray: suitable, western blot: 1:4,000 using cultured MDBK cells extract, immunohistochemistry (frozen sections): 1:2,000 using bovine kidney sections

technique(s)

indirect immunofluorescence: 1:1000 using cultured MDBK cells, immunocytochemistry: suitable, microarray: suitable, immunohistochemistry (frozen sections): suitable, western blot: 1:1000 using cultured MDBK cells extract

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using protease-digested sections of human tongue., western blot: 2-4 μg/mL using rat skeletal muscle extract

technique(s)

western blot: suitable, immunoprecipitation (IP): suitable, immunocytochemistry: suitable

clone

polyclonal

clone

15B8, monoclonal

clone

EA-53, monoclonal

clone

1G5, monoclonal

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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