The exact concentration will be listed on the lot specific Certificate of Analysis. Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:https://www.sigmaaldrich.com/product/sigma/c3865#product-documentation
C3865
Anti-N-Cadherin antibody, Mouse monoclonal
clone GC-4, purified from hybridoma cell culture
Synonym(s):
Anti-A-CAM, Anti-A-Cell Adhesion Molecule
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| Size/SKU | Availability | Price |
|---|---|---|
100 μL | Available to ship TODAYfromMILWAUKEE | $580.00 |
200 μL | Available to ship TODAYfromMILWAUKEE | $724.00 |
About This Item
Conjugate:
unconjugated
Clone:
GC-4, monoclonal
Application:
EM, FACS, ICC, IHC, WB
Citations:
110
$580.00
Available to ship TODAYDetails
A recombinant, preservative-free antibody is available for your target. Try ZRB1126
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
GC-4, monoclonal
form
buffered aqueous solution
mol wt
antigen 135 kDa
species reactivity
chicken, monkey, mouse, human, rabbit, rat
technique(s)
electron microscopy: suitable, flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections, western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
isotype
IgG1
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)
General description
N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.
Application
Anti-N-Cadherin antibody is suitable for the following procedures:
Biochem/physiol Actions
CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.
Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.
Physical form
0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
Other Notes
Clone GC-4 is also known as GB-9.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| description clone GC-4, purified from hybridoma cell culture | description clone GC-4, ascites fluid | description clone CH-19, ascites fluid | description clone DCS-266, purified from hybridoma cell culture |
| species reactivity chicken, monkey, mouse, human, rabbit, rat | species reactivity chicken, mouse, human, rabbit, rat | species reactivity canine, frog, snake, guinea pig, chicken, pig, feline, bovine, rabbit, hamster, Psammomys (sand rat), goat, rat, human, sheep, mouse | species reactivity human |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| clone GC-4, monoclonal | clone GC-4, monoclonal | clone CH-19, monoclonal | clone DCS-266, monoclonal |
| antibody form purified immunoglobulin | antibody form ascites fluid | antibody form ascites fluid | antibody form purified from hybridoma cell culture |
| Gene Information human ... CDH2(1000) | Gene Information human ... CDH2(1000) | Gene Information human ... CDH1(999), CDH2(1000), CDH3(1001) | Gene Information human ... CDH1(999) |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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