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Colchicine

Name: Colchicine
Brand: SIGMA
Price: 130 USD
Availability: InStock

suitable for plant cell culture, BioReagent, ≥95% (HPLC)

Synonym(s):

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

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Size/SKU	Availability	Price
500 mg	Available to ship TODAYfromMILWAUKEE	$130.00
1 g	Available to ship TODAYfromMILWAUKEE	$218.00
5 g	Estimated to ship onNovember 24, 2026fromMILWAUKEE	$812.00

About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₅NO₆

CAS Number:

64-86-8

Molecular Weight:

399.44

UNSPSC Code:

10171502

NACRES:

NA.72

PubChem Substance ID:

24892656

EC Number:

200-598-5

Beilstein/REAXYS Number:

2228813

MDL number:

MFCD00078484

Assay:

≥95% (HPLC)

Form:

powder

$130.00

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Properties

product line

BioReagent

Quality Segment

200

assay

≥95% (HPLC)

form

powder

technique(s)

cell culture | plant: suitable

mp

150-160 °C (dec.) (lit.)

application(s)

agriculture

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)
mouse ... Abcb1a(18671), Abcb1b(18669)

Description

General description

Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C.

Application

Colchicine has been used:

as an inhibitor of tubulin polymerization in bone-marrow-derived macrophages
for the inhibition of in vitro neurite outgrowth in human neuronal cells
as microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)

Biochem/physiol Actions

Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.

Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis.

Preparation Note

Preparation and Use

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Show Differences

1 of 1

This Item	PHL89610	Y0001958	Y0002460
Sigma-Aldrich C3915 Colchicine	PHL89610 Colchicine	Y0001958 Colchicine for system suitability A	Y0002460 Colchicine for system suitability B CRS
description suitable for plant cell culture, BioReagent, ≥95% (HPLC)	description phyproof^® Reference Substance	description European Pharmacopoeia (EP) Reference Standard	description (European Pharmacopoeia (EP) Reference Standard)
form powder	form -	form -	form powder
assay ≥95% (HPLC)	assay ≥95.0% (HPLC)	assay -	assay -
Quality Level 200	Quality Level -	Quality Level -	Quality Level -
technique(s) cell culture \| plant: suitable	technique(s) -	technique(s) -	technique(s) -
mp 150-160 °C (dec.) (lit.)	mp 150-160 °C (dec.) (lit.)	mp 150-160 °C (dec.) (lit.)	mp 150-160 °C (dec.) (lit.)
application(s) agriculture	application(s) food and beverages	application(s) pharmaceutical	application(s) pharmaceutical

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H340

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

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