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C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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0.25 unit
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$210.00

About This Item

CAS Number:
107200-92-0
EC Number:
3.4.21.20 (BRENDA, IUBMB)
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD00130750
Specific activity:
≥60 units/mg protein (Bradford)
Biological source:
human leucocytes

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biological source

human leucocytes

Quality Segment

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

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Cathepsin G from human leukocytes lyophilized powder, ≥60 units/mg protein (Bradford)

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Elastase from human leukocytes lyophilized powder, ≥50 units/mg protein (Bradford)

Sigma-Aldrich

E8140

Elastase from human leukocytes

description

lyophilized powder, ≥60 units/mg protein (Bradford)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

clone AHN-11, from mouse

description

lyophilized powder, ≥50 units/mg protein (Bradford)

biological source

human leucocytes

biological source

rabbit

biological source

mouse

biological source

human leucocytes

specific activity

≥60 units/mg protein (Bradford)

specific activity

-

specific activity

-

specific activity

≥50 units/mg protein (Bradford)

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSG(1511)

Gene Information

human ... ELA2(1991), ELANE(1991)

form

lyophilized powder

form

buffered aqueous glycerol solution

form

-

form

lyophilized powder

shipped in

dry ice

shipped in

wet ice

shipped in

-

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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