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C4650

Cholestyramine resin

Synonym(s):

Colestyramine

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25 g

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$252.00
100 g

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$622.00
250 g

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$1,280.00

About This Item

CAS Number:
11041-12-6
UNSPSC Code:
23151817
EC Number:
234-270-8
NACRES:
NA.56
MDL number:
MFCD00130784

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assay

13-17% chloride basis (dried substance)

Quality Segment

form

powder

technique(s)

LPLC: suitable, activity assay: suitable

matrix

polystyrene/divinylbenzene

pH

4—6

capacity

~1.0 meq/g(dry)

Application

Cholestyramine resin has been used:
  • as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
  • to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
  • in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)

Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.

Biochem/physiol Actions

Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.

Other Notes

Quartenary ammonium functional groups attached to cross-linked polystyrene

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This Item
1133004Y0000374BP551
Cholestyramine resin

Sigma-Aldrich

C4650

Cholestyramine resin

USP

USP

1133004

Cholestyramine resin

vibrant-m

Y0000374

Colestyramine

vibrant-m

BP551

Colestyramine

description

-

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

matrix

polystyrene/divinylbenzene

matrix

-

matrix

-

matrix

-

form

powder

form

-

form

-

form

solid

technique(s)

activity assay: suitable, LPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

pH

4—6

pH

-

pH

-

pH

-

assay

13-17% chloride basis (dried substance)

assay

-

assay

-

assay

-

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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