Key Documents

Anti-Calcium Channel (α₂/δ-1 Subunit) antibody produced in rabbit

Name: Anti-Calcium Channel (α<SUB>2</SUB>/δ-1 Subunit) antibody produced in rabbit
Brand: SIGMA
Price: 375 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-CACNA2, Anti-CACNL2A, Anti-CCHL2A, Anti-LINC01112, Anti-lncRNA-N3

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Size/SKU	Availability	Price
0.05 mL	Check Cart for Availability	$375.00
0.2 mL	Check Cart for Availability	$1,120.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

MDL number:

MFCD02686000

Conjugate:

unconjugated

Clone:

polyclonal

Application:

WB CL

Citations:

$375.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat, pig, human

technique(s)

western blot (chemiluminescent): 1:200 using rat brain membranes

UniProt accession no.

P54289

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CACNA2D1(781)
mouse ... Cacna2d1(12293)
rat ... Cacna2d1(25399)

Description

General description

CACNA2D1 (calcium channel, voltage-dependent, α2/δ subunit 1) is a member of a family of GPI-anchored voltage-gated calcium channels (VGCCs)-associated subunits called α2δ. VGCC are composed of three types of subunits- pore-forming α1 and auxiliary β and α2δ subunits.

L-type of Voltage-gated Ca²⁺ Channel.

Immunogen

synthetic peptide corresponding to amino acids 1-15 of α₂ subunit (amino acids 27-41 of rabbit α₂/δ−1 precursor).

Application

Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

CACNA2D1 (calcium channel, voltage-dependent, α2/δsubunit 1) is a type of α2δs, which are involved in the synaptic neurotransmitter release as they are concentrated at the synapses. They have a chaperone-like activity in non-neuronal cells. This protein acts as a target for gabapentin, which is a neuropathic analgesic. Mutations in this gene, in humans result in short QT syndrome (SQTS).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Preparation Note

Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	C1353	C1603	C1478
Sigma-Aldrich C5105 Anti-Calcium Channel (α₂/δ-1 Subunit) antibody produced in rabbit	Sigma-Aldrich C1353 Anti-Calcium Channel (α_1A Subunit) (P/Q-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1603 Anti-Calcium Channel (α_1C Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit	Sigma-Aldrich C1478 Anti-Calcium Channel (α_1B Subunit) (N-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody	description affinity isolated antibody, lyophilized powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Gene Information human ... CACNA2D1(781) mouse ... Cacna2d1(12293) rat ... Cacna2d1(25399)	Gene Information mouse ... Cacna1a(12286) rat ... Cacna1a(25398)	Gene Information mouse ... Cacna1c(12288)	Gene Information mouse ... Cacna1b(12287) rat ... Cacna1b(257648)
UniProt accession no. P54289	UniProt accession no. P54282	UniProt accession no. Q13936	UniProt accession no. Q02294

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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