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C5992

Anti-Cytokeratin, pan antibody, Mouse monoclonal

Name: Anti-Cytokeratin, pan antibody, Mouse monoclonal
Brand: SIGMA
Price: 149 EUR

clone PCK-26, purified from hybridoma cell culture

Sinonimo/i:

Monoclonal Anti-pan-Cytokeratin, Anti-Cytokeratin, Anti-Cytokeratin - Monoclonal Anti-Cytokeratin, pan antibody produced in mouse

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A voi/SKU	Disponibilità	Prezzo
25 μL	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	149,00 €
100 μL	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	432,00 €
200 μL	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	586,00 €

Informazioni su questo articolo

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

PCK-26, monoclonal

Application:

DB, ICC, IHC, WB

Citations:

149,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

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Proprietà

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

PCK-26, monoclonal

form

buffered aqueous solution

species reactivity

human, chicken, snake, hamster, pig, goat, feline, bovine, carp, rat, rabbit, canine, lizard, sheep, mouse, guinea pig

packaging

antibody small pack of 25 μL

concentration

~1.5 mg/mL

technique(s)

dot blot: suitable, immunocytochemistry: suitable, immunohistochemistry: 10-20 μg/mL using human placenta or skin, western blot: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

bovine ... Krt1(100301161)
dog ... Krt1(444857)
human ... KRT1(3848), KRT5(3852), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856), KRT8(3856)
mouse ... KRT1(16678), KRT1(16678), KRT1(16678), Krt1(16678), Krt5(110308), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691), Krt8(16691)
rat ... Krt1(300250), Krt2-5(369017), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626), Krt2-8(25626)

Descrizione

General description

Monoclonal Anti-Pan Cytokeratin (mouse IgG1 isotype) is derived from the PCK-26 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a cytokeratin preparation from human epidermis. Cytokeratins are a group of at least 29 different proteins. They are characteristic of epithelial and trichocytic cells. Cytokeratin peptide 1 (68 kDa) is expressed together with cytokeratin 10 in the suprabasal cell layers or the differentiation compartment of the epidermis. Its expression increases with epidermal maturation and is modified post translationally in terminally differentiated keratinocytes of the stratum corneum. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification.

Immunogen

cytokeratin from human epidermis.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Monoclonal Anti-Cytokeratin, pan antibody produced in mouse has been used in:

immunoblotting
immunohistochemistry
Immunocytochemistry
dot blotting

Biochem/physiol Actions

Cytokeratin facilitates the typing of normal, metaplastic, and neoplastic cells and may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas, and neural tumors. It is also useful in detecting micrometastases in lymph nodes and other tissues, and for determining the origin of poorly differentiated tumors.

The antibody recognizes an epitope located on the Type II cytokeratins 1, 5, 6, and 8. PCK-26 is a broad spectrum antibody which reacts specifically with a variety of normal, reactive, and neoplastic epithelial tissues. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	C2931	F3418	MAB3412
Sigma-Aldrich C5992 Anti-Cytokeratin, pan antibody, Mouse monoclonal	Sigma-Aldrich C2931 Monoclonal Anti-Cytokeratin, pan antibody produced in mouse	Sigma-Aldrich F3418 Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse	Sigma-Aldrich MAB3412 Anti-Cytokeratin AE1/AE3 Antibody, recognizes acidic & basic cytokeratins, clone AE1/AE3
antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified antibody
Gene Information bovine ... Krt1(100301161) dog ... Krt1(444857) human ... KRT1(3848), KRT5(3852), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856), KRT8(3856) mouse ... KRT1(16678), KRT1(16678), KRT1(16678), Krt1(16678), Krt5(110308), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691), Krt8(16691) rat ... Krt1(300250), Krt2-5(369017), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626), Krt2-8(25626)	Gene Information bovine ... Krt1(100301161) human ... KRT1(3848), KRT13(3858), KRT13(3858), KRT18(3875), KRT18(3875), KRT4(3851), KRT4(3851), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856) mouse ... Krt1(16678), Krt10(16661), Krt10(16661), Krt13(16663), Krt13(16663), Krt18(16668), Krt18(16668), Krt4(16682), Krt4(16682), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691) rat ... Krt1(300250), Krt1-18(706059), Krt1-18(706059), Krt10(450225), Krt10(450225), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626)	Gene Information bovine ... Krt1(100301161) human ... KRT1(3848), KRT13(3858), KRT13(3858), KRT18(3875), KRT18(3875), KRT4(3851), KRT4(3851), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856) mouse ... Krt1(16678), Krt10(16661), Krt10(16661), Krt13(16663), Krt13(16663), Krt18(16668), Krt18(16668), Krt4(16682), Krt4(16682), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691) rat ... Krt1(300250), Krt1-18(706059), Krt1-18(706059), Krt10(450225), Krt10(450225), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626)	Gene Information bovine ... Krt1(100301161) human ... KRT1(3848) mouse ... Krt1(16678) rat ... Krt1(300250)
species reactivity human, chicken, snake, hamster, pig, goat, feline, bovine, carp, rat, rabbit, canine, lizard, sheep, mouse, guinea pig	species reactivity bovine, mouse, frog, human, kangaroo rat, rat	species reactivity bovine, mouse, frog, human, kangaroo rat, rat	species reactivity chicken, mouse, monkey, human, rabbit, bovine, rat
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate FITC conjugate	conjugate -
clone PCK-26, monoclonal	clone C-11, monoclonal	clone C-11, monoclonal	clone AE1/AE3, monoclonal

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