Skip to Content
MilliporeSigma

Skip To

C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

Synonym(s):

Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
100 mg

Available to ship TODAY

$78.00
1 g

Available to ship TODAY

$283.00

About This Item

Empirical Formula (Hill Notation):
C21H21N·HCl·1.5H2O
CAS Number:
Molecular Weight:
350.88
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
213-535-1
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid

$78.00


Available to ship TODAYDetails


​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (TLC)

form

solid

color

white to slightly yellow

solubility

ethanol: soluble, methanol: soluble

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24

InChI

1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2

InChI key

ZEAUHIZSRUAMQG-UHFFFAOYSA-N

Gene Information

Application

Cyproheptadine hydrochloride sesquihydrate has been used in:
  • testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
  • the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
  • the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

Biochem/physiol Actions

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
279072PHR26841161000
description

≥98% (TLC), solid

description

99%

description

pharmaceutical secondary standard, certified reference material

description

United States Pharmacopeia (USP) Reference Standard

form

solid

form

solid

form

solid

form

-

assay

≥98% (TLC)

assay

99%

assay

-

assay

-

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

-

solubility

methanol: soluble

solubility

1 M NH4OH: soluble 25 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

-

color

white to slightly yellow

color

-

color

-

color

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-


Still not finding the right product?


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters