This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
5-HT synthesis inhibitor, solid
Sustainability features
Synonym(s):
PCP, PCPA
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Estimated to ship onDecember 04, 2026fromMILWAUKEE | $169.00 |
25 g | Available to ship TODAYfromMILWAUKEE | $603.00 |
About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
Product Name
4-Chloro-DL-phenylalanine,
form
solid
Quality Segment
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product, Sustainability features
mp
>240 °C (dec.) (lit.)
storage temp.
room temp
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
Application
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
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This Item | |||
|---|---|---|---|
| description - | description mol wt 4,000-15,000 by viscosity | description 98% | description 98% |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form solid | form solid | form - | form solid |
| Gene Information human ... TPH1(7166), TPH2(121278) | Gene Information - | Gene Information - | Gene Information - |
| storage temp. room temp | storage temp. −20°C | storage temp. - | storage temp. - |
| mp >240 °C (dec.) (lit.) | mp - | mp - | mp 187-195 °C |
| greener alternative category | greener alternative category | greener alternative category | greener alternative category |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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For in vivo experiment, does this have to be dissolved in 1N HCL?
1 answer-
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