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Monoclonal Anti-β-Catenin antibody produced in mouse

Name: Monoclonal Anti-β-Catenin antibody produced in mouse
Brand: SIGMA
Price: 769 CAD

clone 6F9, ascites fluid

Synonym(s):

Anti-CTNNB, Anti-EVR7, Anti-MRD19, Anti-NEDSDV, Anti-armadillo

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Size/SKU	Availability	Price
0.2 mL	Please contact Customer Service for Availability	$769.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00282178

Conjugate:

unconjugated

Clone:

6F9, monoclonal

Application:

ARR, IF, WB

Citations:

$769.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

6F9, monoclonal

mol wt

antigen 94 kDa

contains

15 mM sodium azide

species reactivity

human, chicken, canine, bovine

technique(s)

indirect immunofluorescence: 1:1,000 using cultured MDBK cells, microarray: suitable, western blot: 1:1,000 using cultured MDBK cells extract

isotype

IgG1

UniProt accession no.

P35222

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CTNNB1(1499)

Description

General description

Monoclonal Anti- β -Catenin (mouse IgG1 isotype) is derived from the 6F9 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. CTNNB1 (catenin β 1) gene is mapped to human chromosome 3p21. The protein encoded is also called as cadherin-associated protein.The encoded protein β-catenin is localized to the nucleus. Monoclonal antibody reacting specifically with β -catenin is an essential tool in defining the interactions and distributions of β -catenin and its relationships with other catenins and cadherins in various cells and tissues.

Immunogen

recombinant chicken β-catenin.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Monoclonal Anti-β-Catenin antibody produced in mouse has been used in:

immunohistochemistry
immunofluorescence
immunoblotting

Biochem/physiol Actions

In Wnt/β-catenin signal pathway, β-Catenin participates as a signal transduction molecule. The pathway is associated with development, tissue homeostasis and oncogenic transcription. Upregulation of the gene is associated with glioma cell proliferation. The encoded protein has dual function that regulates the coordination of cell-cell adhesion by linking cytoskeleton and cellular junctions and gene transcription. Wnt/β-catenin signal pathway is known to induce progression of colon cancer progression. It is useful for differential diagnosis of Osteoblastoma (OB) and osteosarcoma (OS). β-catenin signaling pathway may contribute to cholangiocarcinoma (CCA) cell proliferation. Monoclonal antibody reacting specifically with β -catenin is an essential tool in defining the interactions and distributions of β -catenin and its relationships with other catenins and cadherins in various cells and tissues.

The antibody does not cross-react with plakoglobin (γ-catenin).

Physical form

Supplied as ascites fluid with 15 mM sodium azide as a preservative.

Preparation Note

For extended storage freeze in working aliquots. For continuous use, store at 2-8 °C. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200720	C4231	SAB4500541
Sigma-Aldrich C7082 Monoclonal Anti-β-Catenin antibody produced in mouse	Sigma-Aldrich SAB4200720 Anti-β-Catenin antibody, Mouse monoclonal	Sigma-Aldrich C4231 Anti-phospho-β-Catenin (pSer³³/pSer³⁷) antibody, Mouse monoclonal	Sigma-Aldrich SAB4500541 Anti-Catenin-β antibody produced in rabbit
description clone 6F9, ascites fluid	description clone 15B8, purified from hybridoma cell culture	description clone BC-22, purified from hybridoma cell culture	description affinity isolated antibody
antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Gene Information human ... CTNNB1(1499)	Gene Information human ... CTNNB1(1499) mouse ... Ctnnb1(12387) rat ... Ctnnb1(84353)	Gene Information human ... CTNNB1(1499) mouse ... Ctnnb1(12387) rat ... Ctnnb1(84353)	Gene Information human ... CTNNB1(1499)
species reactivity human, chicken, canine, bovine	species reactivity chicken, mouse, human, rat, monkey, hamster, bovine, canine	species reactivity mouse, human, rat, chicken	species reactivity rat, mouse, human
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
clone 6F9, monoclonal	clone 15B8, monoclonal	clone BC-22, monoclonal	clone polyclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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