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C7113

Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal

Name: Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal
Brand: SIGMA
Price: 172 EUR

clone 4901, purified from hybridoma cell culture

Sinonimo/i:

Anti-CALC, Anti-CCALCI, Anti-CGRP-I

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A voi/SKU	Disponibilità	Prezzo
25 μL	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	172,00 €
100 μL	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	566,00 €

Informazioni su questo articolo

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162203

Conjugate:

unconjugated

Clone:

4901, monoclonal

Application:

ELISA (i), ICC, Neutral, RIA

Citations:

172,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

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Proprietà

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

4901, monoclonal

form

buffered aqueous solution

species reactivity

rat, human, canine

packaging

antibody small pack of 25 μL

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, indirect ELISA: 0.5 μg/mL using rat α-CGRP, neutralization: suitable, radioimmunoassay: suitable

isotype

IgG1

UniProt accession no.

P01258

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Descrizione

General description

CGRP (Calcitonin gene-related peptide) belongs to calcitonin family and is expressed mainly in the central and peripheral nervous systems. It is a strong endogenous vasodilator. CGRP concentration increases in migraine attacks and hence, it is involved in the pathogenesis of migraine headaches . Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunoneutralization and radioimmunoassay. Mouse anti-calcitonin gene-related peptide antibody reacts specifically with an epitope present within the C-terminal ten amino acids of rat α-CGRP and also has shown cross reactivity with α and β-CGRP of humans and dogs.

Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options
Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes rat α-CGRP. The antibody cross-reacts with human and dog α- and β-CGRP.

Immunogen

rat α-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat α-CGRP.

Application

Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunocytochemistry and immunohistochemistry. It can also be used in ELISA.

Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for ELISA at a working concentration of 0.25- 0.5 μg/ml. The antibody may be used for immunofluorescence at a working dilution of 1:100 in rat nerve fibres and human dorsal root ganglia.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	C9487	C8198	N0913
Sigma-Aldrich C7113 Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal	Sigma-Aldrich C9487 Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse	Sigma-Aldrich C8198 Anti-Calcitonin Gene Related Peptide antibody produced in rabbit	Sigma-Aldrich N0913 Anti-Neurocan antibody, Mouse monoclonal
description clone 4901, purified from hybridoma cell culture	description clone CD8, purified immunoglobulin, buffered aqueous solution	description whole antiserum	description clone 650.24, purified from hybridoma cell culture
clone 4901, monoclonal	clone CD8, monoclonal	clone polyclonal	clone 650.24, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form whole antiserum	antibody form purified from hybridoma cell culture
species reactivity rat, human, canine	species reactivity guinea pig, human	species reactivity rat	species reactivity rat
biological source mouse	biological source mouse	biological source rabbit	biological source mouse
Gene Information human ... CALCA(796) rat ... Calca(24241)	Gene Information human ... CALCA(796) rat ... Calca(24241)	Gene Information rat ... Calca(24241)	Gene Information rat ... Ncan(58982)

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Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c