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C7113

Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal

clone 4901, purified from hybridoma cell culture

Synonym(s):

Anti-CALC, Anti-CCALCI, Anti-CGRP-I

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Pack SizeSKUAvailabilityPrice
25 μL

Available to ship TODAYfromMILWAUKEE

$201.00
100 μL

Available to ship TODAYfromMILWAUKEE

$665.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00162203
Conjugate:
unconjugated
Clone:
4901, monoclonal
Application:
ELISA (i), ICC, Neutral, RIA
Citations:
39

$201.00

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

4901, monoclonal

form

buffered aqueous solution

species reactivity

rat, human, canine

packaging

antibody small pack of 25 μL

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, indirect ELISA: 0.5 μg/mL using rat α-CGRP, neutralization: suitable, radioimmunoassay: suitable

isotype

IgG1

UniProt accession no.

P01258

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

General description

CGRP (Calcitonin gene-related peptide) belongs to calcitonin family and is expressed mainly in the central and peripheral nervous systems. It is a strong endogenous vasodilator. CGRP concentration increases in migraine attacks and hence, it is involved in the pathogenesis of migraine headaches . Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunoneutralization and radioimmunoassay. Mouse anti-calcitonin gene-related peptide antibody reacts specifically with an epitope present within the C-terminal ten amino acids of rat α-CGRP and also has shown cross reactivity with α and β-CGRP of humans and dogs.
Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options
Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes rat α-CGRP. The antibody cross-reacts with human and dog α- and β-CGRP.

Immunogen

rat α-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat α-CGRP.

Application

Monoclonal anti-calcitonin gene-related peptide antibody can be used in immunocytochemistry and immunohistochemistry. It can also be used in ELISA.
Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for ELISA at a working concentration of 0.25- 0.5 μg/ml. The antibody may be used for immunofluorescence at a working dilution of 1:100 in rat nerve fibres and human dorsal root ganglia.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Calcitonin Gene-Related Peptide antibody, Mouse monoclonal clone 4901, purified from hybridoma cell culture

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species reactivity

rat, human, canine

species reactivity

guinea pig, human

species reactivity

rat

species reactivity

rat, bovine, pig, mouse, rabbit, feline, human

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

whole antiserum

antibody form

purified from hybridoma cell culture

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Gene Information

human ... CALCA(796)
rat ... Calca(24241)

Gene Information

rat ... Calca(24241)

Gene Information

human ... PRPH(5630)
mouse ... Prph(19132)
rat ... Prph(24688)

clone

4901, monoclonal

clone

CD8, monoclonal

clone

polyclonal

clone

8G2, monoclonal

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000547321
0000547321
0000515663
0000515663
0000493380

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Related Content

Ian De Proost et al.
Histochemistry and cell biology, 128(4), 301-316 (2007-08-11)
Studying depolarisation induced calcium entry in our recently developed in situ lung slice model for molecular live cell imaging of selectively visualised pulmonary neuroepithelial bodies (NEBs), exemplified the need for information on the localisation of voltage-gated calcium channels (Ca(v)) in
Stephen L Holtz et al.
The Journal of comparative neurology, 523(1), 139-161 (2014-09-05)
The ventroposterior medialis parvocellularis (VPMpc) nucleus of the thalamus, the thalamic relay nucleus for gustatory sensation, receives primary input from the parabrachial nucleus, and projects to the insular cortex. To reveal the unique properties of the gustatory thalamus in comparison
Claire Magnussen et al.
Molecular pain, 11, 31-31 (2015-05-28)
Neuropeptide Y (NPY) has been implicated in the modulation of pain. Under normal conditions, NPY is found in interneurons in the dorsal horn of the spinal cord and in sympathetic postganglionic neurons but is absent from the cell bodies of
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Global Trade Item Number

SKUGTIN
C7113-100UL04061838162878
C7113-25UL04061838453624

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