If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
C7698
Cycloheximide
from microbial, ≥94% (TLC)
Synonym(s):
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 g | Available to ship TODAYfromMILWAUKEE | $92.50 | |
| 5 g | Available to ship TODAYfromMILWAUKEE | $251.00 |
About This Item
biological source
microbial
assay
≥94% (TLC)
form
powder
color
white to off-white
solubility
ethanol: soluble, clear to hazy
antibiotic activity spectrum
fungi, yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
Gene Information
human ... FKBP1A(2280), PIN1(5300)
General description
In cell biology and biochemical research, Cycloheximide showcases a dual nature concerning Apoptosis Induction, inducing or inhibiting apoptosis depending on the cell type. Its rapid and reversible effects make it an ideal choice for studying cellular processes and determining protein half-life. Cycloheximide also finds extensive applications in biomedical research, where it inhibits protein synthesis in eukaryotic cells studied in vitro (outside of organisms) and its effects are rapidly reversed by simply removing it. This makes Cycloheximide a go-to choice for exploring cell biology, biomedical and biochemical research, offering precise control and versatility in experiments.
Application
- In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
- It has been used to inhibit translation in mammalian cells.
- It has been used to suppress fungal growth.[1]
Biochem/physiol Actions
Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium
Features and Benefits
- High-quality antibiotic suitable for multiple research applications
- Commonly used in Cell Biology and Biochemical applications
Preparation Note
only to qualified or authorized persons.
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder or crystals | form powder | form liquid |
| assay ≥94% (TLC) | assay ≥95% (HPLC) | assay - | assay - |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility ethanol: soluble, clear to hazy | solubility - | solubility - | solubility - |
| color white to off-white | color white to light beige | color - | color - |
| biological source microbial | biological source microbial | biological source - | biological source - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7698-5G | 04061835556229 |
| C7698-1G | 04061835506156 |
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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