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C7806

Bovine Collagen Type II

from bovine nasal septum, powder, suitable for ELISA assays

Synonym(s):

Collagen from bovine

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5 mg

Available to ship TODAYfromMILWAUKEE

$312.00
10 mg

Available to ship TODAYfromMILWAUKEE

$536.00

About This Item

CAS Number:
9007-34-5
UNSPSC Code:
12352202
NACRES:
NA.61
EC Number:
232-697-4
MDL number:
MFCD00130825
Form:
powder
Biological source:
bovine nasal septum

$312.00

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Product Name

Collagen from bovine nasal septum, Bornstein and Traub Type II, powder

biological source

bovine nasal septum

Quality Segment

200

form

powder

technique(s)

ELISA: suitable

solubility

aqueous acid: soluble

UniProt accession no.

P02459

storage temp.

2-8°C

Gene Information

bovine ... COL2A1(407142)

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate.

Application

Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.
Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA). It has also been used as a component in the emulsified agent to induce arthritis in rats.

Biochem/physiol Actions

Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process.

Preparation Note

An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.
Collagen Type II is a triple helix composed of three α1(II) strands.
Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984).

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Collagen from rat tail Bornstein and Traub Type I, powder, BioReagent, suitable for cell culture

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description

Bornstein and Traub Type II, powder

description

Bornstein and Traub Type II, powder

description

Bornstein and Traub Type I, powder

description

Bornstein and Traub Type I, powder, BioReagent, suitable for cell culture

technique(s)

ELISA: suitable

technique(s)

-

technique(s)

cell culture | stem cell: suitable

technique(s)

cell culture | mammalian: suitable

biological source

bovine nasal septum

biological source

bovine cartilage (tracheal)

biological source

rabbit skin

biological source

rat tail

form

powder

form

powder

form

powder

form

powder

Gene Information

bovine ... COL2A1(407142)

Gene Information

cow ... COL2A1(407142)

Gene Information

rabbit ... COL1A2(100008997)

Gene Information

rat ... Col1a1(29393)

UniProt accession no.

P02459

UniProt accession no.

P02459

UniProt accession no.

Q28668

UniProt accession no.

P02454

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Questions

  1. Is it working for mice model - (C57BL/6 and DBA/1) strain.

    1 answer

    1. Yes, this product is known for its efficacy with these mouse strains for induction of collagen-induced arthritis. The following citation may be of interest for reference.

      Pfeifle, Rene. Analysis of the role of the IL-23/Th17 axis on B cell-mediated autoimmunity. Diss. Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017.
      https://open.fau.de/items/0f95587e-e40b-4858-9764-36f55d70d664

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