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Anti-Aggrecan Antibody

Name: Anti-Aggrecan Antibody
Brand: SIGMA
Price: 506 CAD

mouse monoclonal, CS-56

Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse

Synonym(s):

Chondroitin Sulfate Antibody, Chondroitin Sulfate Antibody - Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse, Cs56 Antibody

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Pack Size	SKU	Availability	Price
100 μL		Please contact Customer Service for Availability	$506.00
0.2 mL		Check Cart for Availability	$677.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164568

Conjugate:

unconjugated

Clone:

CS-56, monoclonal

Application:

ARR, IF

Citations:

240

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Properties

Product Name

Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse, clone CS-56, ascites fluid

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CS-56, monoclonal

species reactivity

chicken, bovine, mouse, human, pig, rabbit, rat

technique(s)

indirect immunofluorescence: 1:200 using bovine mammary gland epithelial (BMGE) cells, microarray: suitable

isotype

IgM

UniProt accession no.

P16112

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACAN(176)
mouse ... Acan(11595)
rat ... Acan(58968)

Description

General description

Chondroitin sulfate is a linear polysaccharide composed of alternating disaccharide glucuronic acid and N-acetylgalactosamine. It contains proteoglycan (PG) of the extracellular matrix (ECM). Monoclonal Anti-Chondroitin Sulfate (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
This product can be found as purified product that was produced using cell culture hybridoma (SAB4200696)

Immunogen

Ventral membranes of chicken gizzard fibroblasts

Application

Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse was used:

in immunohistochemistry as primary antibody to study of spinal cords and brain cryosections.
in ELISA and western blot for purification of soluble forms of myelin-associated glycoprotein (MAG) and neural cell adhesion molecule (N-CAM).
in flow cytometry studies.
as primary antisera in a study of TGF-β regulation.

Monoclonal Anti-Chondroitin Sulfate can also be used to study chondroitin sulfate proteoglycan (CSPG) distribution and its relationships to specific cell-substrate contacts. It is also suitable for microarray and indirect immunofluorescence at the dilution of 1:200 by using bovine mammary gland epithelial (BMGE) cells.

Biochem/physiol Actions

Chondroitin sulfate is involved in tumor invasion and also plays a vital role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. In Chondroitin sulfate proteoglycan (CSPG), proteoglycan part is involved in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. Chondroitin sulfate is used in osteoarthritis treatment. Upregulation of chondroitin sulfate proteoglycans is observed after neuronal injury. It possess the ability to inhibit axonal regeneration.

The antibody has been reported to be specific for the glycosaminoglycan (GAG) portion of native chondroitin sulfate proteoglycan (CSPG). The antibody reacts specifically with chondroitin sulfate types A and C but not with type B (dermatan sulfate), and may be used for localization of chondroitin sulfate in tissues and cultured fibroblasts.

Preparation Note

For continuous use, store at 2-8 °C for up to one month.
For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Other Notes

This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal
clone CS-56, purified from hybridoma cell culture

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	SAB4200696	S5768	C9848
Sigma-Aldrich C8035 Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse	Sigma-Aldrich SAB4200696 Anti-Chondroitin Sulfate antibody, Mouse monoclonal	Sigma-Aldrich S5768 Monoclonal Anti-Synaptophysin antibody produced in mouse	Sigma-Aldrich C9848 Monoclonal Anti-Calbindin-D-28K antibody produced in mouse
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity chicken, bovine, mouse, human, pig, rabbit, rat	species reactivity mouse, chicken, bovine, human	species reactivity pig, rat, human, guinea pig	species reactivity mouse, human, guinea pig, canine, sheep, rat, pig, rabbit, feline, bovine, goat
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate unconjugated
clone CS-56, monoclonal	clone CS-56, monoclonal	clone SVP-38, monoclonal	clone CB-955, monoclonal
antibody form ascites fluid	antibody form purified from hybridoma cell culture, purified immunoglobulin	antibody form ascites fluid	antibody form ascites fluid
Gene Information human ... ACAN(176) mouse ... Acan(11595) rat ... Acan(58968)	Gene Information human ... CSPG4(1464)	Gene Information human ... SYP(6855) rat ... Syp(24804)	Gene Information human ... CALB1(793) mouse ... Calb1(12307) rat ... Calb1(83839)

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000540042

0000453312

0000453313

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Global Trade Item Number

SKU	GTIN
C8035-100UL	04061833521540
C8035-.2ML	04061833521533