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C8138

Chlorpromazine hydrochloride

≥98% (TLC), powder, D2 dopamine receptor antagonist

Synonym(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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5 g

Available to ship TODAYfromMILWAUKEE

$128.00
25 g

Available to ship TODAYfromMILWAUKEE

$542.00
100 g

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$1,200.00

About This Item

Empirical Formula (Hill Notation):
C17H19ClN2S · HCl
CAS Number:
69-09-0
Molecular Weight:
355.33
NACRES:
NA.77
PubChem Substance ID:
57654045
UNSPSC Code:
12352200
EC Number:
200-701-3
MDL number:
MFCD00012654
Beilstein/REAXYS Number:
3779989
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

$128.00

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Product Name

Chlorpromazine hydrochloride, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

194-196 °C

solubility

water: 50 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR2A(3356)

Application

Chlorpromazine hydrochloride has been used:
  • as an antagonists for calmodulin kinase[1]
  • as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
  • as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

1 of 1

This Item
31679C09821125006
Chlorpromazine hydrochloride ≥98% (TLC)

Sigma-Aldrich

C8138

Chlorpromazine hydrochloride

Chlorpromazine hydrochloride VETRANAL®, analytical standard

Supelco

31679

Chlorpromazine hydrochloride

Chlorpromazine hydrochloride meets USP testing specifications

Sigma-Aldrich

C0982

Chlorpromazine hydrochloride

Chlorpromazine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1125006

Chlorpromazine hydrochloride

assay

≥98% (TLC)

assay

-

assay

98.0-101.5% dry basis

assay

-

form

powder

form

-

form

solid

form

-

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

-

solubility

water: 50 mg/mL

solubility

-

solubility

water: soluble 50 g/L

solubility

-

originator

GlaxoSmithKline

originator

-

originator

-

originator

-

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HTR2A(3356)

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ0803
MKCW1593
MKCT3985
MKCQ9778
MKCN7684

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Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane
Dandekar P, et al.
Journal of Material Chemistry B: Materials for Biology and Medicine, 3(13), 2590-2598 (2015)
Anne Y Hung et al.
Journal of neurophysiology, 97(3), 2465-2479 (2007-03-14)
The translation of prior activity into changes in excitability is essential for memory and the initiation of behavior. After brief synaptic input, the bag cell neurons of Aplysia californica undergo a nearly 30-min afterdischarge to release egg-laying hormone. The present
Jim Baggen et al.
Nature communications, 10(1), 3171-3171 (2019-07-20)
Enteroviruses are a major cause of human disease. Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a pan-enterovirus host factor and potential drug target. In this study, we identify a possible mechanism of PLA2G16 evasion by employing a dual glycan
View All Related Papers

Global Trade Item Number

SKUGTIN
C8138-25G04061833629390
C8138-100G04061833629383
C8138-5G04061833521847

Questions

  1. Dear, I bought your product C8138 Chlorpromazine. I have few practical questions: - Can it be dissolved in DMSO? - Can it be dissolved in Phosphate-buffered saline? - What is the storage temperature of the dissolved product?

    1 answer

    1. This product is tested for solubility in water at 50 mg/mL. Other published sources state that this compound is also soluble in organic solvents such as DMSO and alcohols. Solution stability studies have not been perofrmed, however the Chlorpromazine HCl analytical standard, product C-904, is a 1 mg/mL solution in methanol. This item is not assigned an expiration date and is considered stable for at least 1 year from the date of shipment when stored at ?20°C.

      Please see the link below to review the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/966/223/c8138pis.pdf

      Please see the link below to review a publication related to the stability of this compound in water:
      http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705283/pdf

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