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Merck

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C8198

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit

whole antiserum

Sinônimo(s):

CGRP Antibody - Anti-Calcitonin Gene Related Peptide antibody produced in rabbit, Cgrp Antibody, Anti-CGRP

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Para você/SKUDisponibilidadePreço
25 μL
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R$ 1.083,00
0.2 mL
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R$ 7.026,00

Sobre este item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
Citations:
189

R$ 1.083,00


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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

rat

packaging

antibody small pack of 25 μL

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Calca(24241)

General description

Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.

Immunogen

CGRP-KLH

Application

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:
  • dot blot immunoassay
  • fluorescent labeling[1]
  • confocal microscopy[1]
  • immunohistofluorescence[2]
  • epifluorescence imaging[2]

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.

Biochem/physiol Actions

Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).
CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.

Physical form

Supplied as a liquid containing 0.1% sodium azide as a preservative

Preparation Note

For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
delipidized

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este Item
C5348N3908N9528
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

antibody form

whole antiserum

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

antibody form

whole antiserum

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal


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Classe de armazenamento

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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