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C8487

Anti-Caspase 3, Active antibody produced in rabbit

Name: Anti-Caspase 3, Active antibody produced in rabbit
Brand: SIGMA
Price: 285926 KRW
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

동의어(들):

Activated Caspase 3 Antibody, Activated Caspase 3 Antibody - Anti-Caspase 3, Active antibody produced in rabbit, Anti-Apopain, Anti-CPP32, Anti-Yama

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팩 크기/SKU	재고 정보	가격 (VAT 별도)
25 μL	예상 입고일2026년 7월 30일재고 수량 조회Seoul Warehouse South Korea	₩285,926
100 μL	구입 가능 여부는 고객센터에 문의하십시오.	₩944,762
200 μL	구입 가능 여부는 고객센터에 문의하십시오.	₩1,221,959

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01321906

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, WB

Citations:

129

₩285,926

예상 입고일2026년 7월 30일세부사항

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도움 문의

속성

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, bovine, human, pig, canine, mouse

packaging

antibody small pack of 25 μL

technique(s)

indirect immunofluorescence: 1:1,000 using human epitheloid carcinoma HeLa cell line, treated with staurosporine, microarray: suitable, western blot: 1:500 using recombinant human caspase 3, active (Sigma Product No. C1224)

UniProt accession no.

P42574

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASP3(836)
mouse ... Casp3(12367)
rat ... Casp3(25402)

설명

General description

Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3 is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3 is mapped to human chromosome 4q35.1.

Caspases are a family of intracellular proteases that mediate cell death and the principal effectors of apoptosis. There are 14 different caspases have identified which can be grouped into three different subfamilies based on their substrate specificities. Caspase 3 is also known as CPP32, Yama, apopain. Among all the types, caspase 3, a cytosolic protein, found in cells as an inactive 32 kDa proenzyme.

Immunogen

Synthetic peptide corresponding to the cleavage site of human caspase 3 conjugated to KLH.

Application

Anti-Caspase 3, Active antibody has been used:

for western blotting of cytochrome c for caspase activation
as primary antibody in immunofluorescence staining of embryos and postnatal mice cryosections
in Western blot analysis of activated caspase 3
as a primary antibody in immunodetection of rat brain sections

Biochem/physiol Actions

Caspase 3 is one of the key effectors of apoptosis. It acts downstream of caspase 9 in the apoptotic pathway. During apoptosis, it gets activated by proteolytic cleavage into the 17-19 kDa (p17, p18) and 12 kDa (p12) active subunits. Any alteraion in CASP-3 in mice, causes premature lethality. It has also shown that the deletion of gene affects brain development resulting of hyperplasias and disorganized cell deployement. Clinically it is related to Huntington disease (HD). Caspase 3 brings about cell death by activating CAD (caspase activated DNAse I), an endonuclease that causes degradation of chromosomal DNA.

Physical form

Supplied in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Store at –20 °C. For continuous use, the product may be storage, the product may be stored at 2-8 °C for up to one month. For prolonged storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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차이점 표시

1 of 1

이 품목	C5737	SAB5700153	SAB4504126
$Anti-Caspase 3, Active antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C8487 Anti-Caspase 3, Active antibody produced in rabbit	Sigma-Aldrich C5737 Monoclonal Anti-Caspase 3 antibody produced in mouse	Sigma-Aldrich SAB5700153 Anti-Caspase antibody produced in rabbit	Sigma-Aldrich SAB4504126 Anti-phospho-Caspase 3 (pSer¹⁵⁰) antibody produced in rabbit
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
technique(s) indirect immunofluorescence: 1:1,000 using human epitheloid carcinoma HeLa cell line, treated with staurosporine, western blot: 1:500 using recombinant human caspase 3, active (Sigma Product No. C1224), microarray: suitable	technique(s) western blot: 1.0 μg/mL using human Jurkat cells	technique(s) immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000	technique(s) ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
Gene Information human ... CASP3(836) mouse ... Casp3(12367) rat ... Casp3(25402)	Gene Information human ... CASP3(836)	Gene Information human ... CASP3(836)	Gene Information human ... CASP3(836)

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