Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
C8754
Thiamine pyrophosphate
≥95%, powder
Synonym(s):
Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Available to ship TODAYfromMILWAUKEE | $62.10 |
5 g | Available to ship TODAYfromMILWAUKEE | $81.60 |
25 g | Available to ship TODAYfromMILWAUKEE | $331.00 |
100 g | Available to ship TODAYfromMILWAUKEE | $940.00 |
About This Item
Empirical Formula (Hill Notation):
C12H19ClN4O7P2S
CAS Number:
Molecular Weight:
460.77
NACRES:
NA.54
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
205-836-1
MDL number:
Beilstein/REAXYS Number:
3875902
Product Name
Thiamine pyrophosphate, ≥95%
Quality Segment
assay
≥95%
form
powder
solubility
H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless
storage temp.
−20°C
SMILES string
CC1=C(CCOP(OP(O)(O)=O)(O)=O)SC=[N+]1CC2=C(N)N=C(C)N=C2.[Cl-]
InChI
1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H
InChI key
YXVCLPJQTZXJLH-UHFFFAOYSA-N
Application
Thiamine pyrophosphate from Sigma has been used as a substrate to assay the enzymes in golgi lamellae isolated from rat tissue.
Thiamine pyrophosphate has been used:
- for the preparation of chitosan nano-particles
- as a standard for vitamin B1 and its derivative in high-performance
- liquid chromatography (HPLC) analysis
- immunofluorescence
Biochem/physiol Actions
Thiamine pyrophosphate (TPP) is a coenzyme of transketolase, that catalyzes the cleavage of ribulose-5-phosphate. This reaction leads to the formation of D-glyceraldehyde-3-phosphate. It requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde. TPP is capable of decarboxylating hydroxypyruvate in the presence of an ′acceptor aldehyde′.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥95% | description Pharmaceutical Secondary Standard; Certified Reference Material | description Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. | description 96% (NT) |
| assay ≥95% | assay - | assay ≥97% (titration) | assay 96% (NT) |
| solubility H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless | solubility - | solubility chloroform: soluble, ethanol: soluble | solubility - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level 200 |
| form powder | form - | form liquid | form liquid |
| storage temp. −20°C | storage temp. -10 to -25°C | storage temp. 2-8°C | storage temp. 2-8°C |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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