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D1667

Monoclonal Anti-Dynein (Heavy Chain) antibody produced in mouse

clone 440.4, ascites fluid

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0.2 mL
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€ 497,00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164585
Conjugate:
unconjugated
Clone:
440.4, monoclonal
Application:
ELISA (i), WB
Citations:
10

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

440.4, monoclonal

mol wt

antigen 440 kDa

contains

15 mM sodium azide

species reactivity

human, chicken

technique(s)

indirect ELISA: suitable, western blot: 1:100 using a chick brain extract or Kinesin enriched rat brain extract

isotype

IgG2a

UniProt accession no.

Q8TD57

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DNAH1(25981), DNAH2(146754), DNAH3(55567), DNAH5(1767)

General description

Monoclonal Anti-Dynein (Heavy Chain) (mouse IgG2a isotype) is derived from the 440.4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Dynein axonemal heavy chain 1 (DNAH1) encodes for an inner dynein heavy chain. This gene is mapped to the human chromosome location 3p21.1. DNAH1 is expressed in the testis and other ciliated cells. Dyneins are composed of two or three distinct heavy chains, three intermediate chains and at least four light chains.

Immunogen

cytoplasmic dynein from chicken embryo brain.

Application

Monoclonal Anti-Dynein (Heavy Chain) antibody produced in mouse has been used in:
  • indirect immunofluorescence at 1:50 dilution
  • immunocytochemistry
  • enzyme-linked immunosorbent assay (ELISA)
  • immunoblotting
  • dot blot

Biochem/physiol Actions

Dynein has also been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport. It also regulates the endocytic pathway and the organization of the Golgi apparatus. Mutations in dynein axonemal heavy chain 1 (DNAH1) are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella (MMAF) that leads to asthenozoospermia and male infertility.
Dynein is a motor protein that regulates the movement of organelles to the ‘minus′ end of microtubules. These motor proteins are also involved in spindle organization, retrograde transport and chromosome movement

Physical form

Suppied as ascites fluid with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

species reactivity

human, chicken

species reactivity

guinea pig, human, pig, canine, rabbit, chicken

species reactivity

human, chicken, pig, bovine, rabbit

species reactivity

rabbit, sheep, horse (IgG), goat, human

clone

440.4, monoclonal

clone

hSM-V, monoclonal

clone

MY-21, monoclonal

clone

HP-6017, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... DNAH1(25981), DNAH2(146754), DNAH3(55567), DNAH5(1767)

Gene Information

human ... MYH11(4629)

Gene Information

chicken ... MYLK2(396356)
human ... MYLK2(85366)

Gene Information

-

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000085460
0000188272
0000085460
0000188272
0000099171

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Related Content

Data Sheet - D1667

Instructions

Mariem Ben Khelifa et al.
American journal of human genetics, 94(1), 95-104 (2013-12-24)
Ten to fifteen percent of couples are confronted with infertility and a male factor is involved in approximately half the cases. A genetic etiology is likely in most cases yet only few genes have been formally correlated with male infertility.
Stephanie K Carnes et al.
Journal of virology, 92(20) (2018-08-03)
Human immunodeficiency virus type 1 (HIV-1) infection depends on efficient intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence suggests that this movement is facilitated by the microtubule motor dynein, a large multiprotein complex that interacts
X Wang et al.
Clinical genetics, 91(2), 313-321 (2016-08-31)
This study aimed to investigate the genetic pathogeny of multiple morphological anomalies of the flagella (MMAF), which is a genetically heterogeneous disorder leading to male infertility. Nine patients with severe asthenozoospermia caused by MMAF were recruited. Whole genome sequencing and
View All Related Papers

Global Trade Item Number

SKUGTIN
D1667-.5ML04061838042637
D1667-.2ML04061838099242

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