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Monoclonal Anti-Dihydropyridine Receptor (α₁ Subunit) antibody produced in mouse

Name: Monoclonal Anti-Dihydropyridine Receptor (α<SUB>1</SUB> Subunit) antibody produced in mouse
Brand: SIGMA
Price: 809 USD
Availability: InStock

clone 1A, buffered aqueous solution

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100 μL	Check Cart for Availability	$809.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01633297

Conjugate:

unconjugated

Clone:

1A, monoclonal

Application:

IHC (f), IP, WB CL

Citations:

$809.00

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Properties

conjugate

unconjugated

Quality Segment

200

antibody form

ascites fluid

antibody product type

primary antibodies

clone

1A, monoclonal

form

buffered aqueous solution

mol wt

antigen ~200 kDa

species reactivity

human (weakly), guinea pig, mouse, rat, rabbit

technique(s)

immunohistochemistry (frozen sections): 1:200, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1:500

isotype

IgG1

UniProt accession no.

Q13698

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CACNA1S(779)
mouse ... Cacna1s(12292)
rat ... Cacna1s(682930)

Description

General description

DHP receptor is composed of at least four subunits. The α1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated Na+ channel. The α2 subunit is a large glycoprotein and the other 2 subunits are termed β and γ.

Immunogen

rabbit muscle transverse tubule dihydropyridine (DHP) receptors.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Monoclonal Anti-Dihydropyridine Receptor (α1 Subunit) antibody produced in mouse is suitable for immunoprecipitation, immunohistochemistry at a working dilution of 1:500 and immunoblotting at 1:2000. It was used for the detection and localization of DHPR-1α by western blotting in skeletal muscle tissue sections of mice in a study. The antibody may be used to inhibit the DHP-sensitive calcium current in BC3H1 mouse muscle cells.

Biochem/physiol Actions

Reacts specifically with the α₁ subunit of the DHP receptor. May be used to inhibit the DHP-sensitive calcium current in BC3H1 mouse muscle cells. By immunohistochemistry, double rows of discrete punctate staining represent pairs of triads on the opposing sides of the Z-lines.

The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type Ca²⁺ channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	A274	R129	SAB5200022
Sigma-Aldrich D218 Monoclonal Anti-Dihydropyridine Receptor (α₁ Subunit) antibody produced in mouse	Sigma-Aldrich A274 Monoclonal Anti-H⁺/K⁺ ATPase (β Subunit) antibody produced in mouse	Sigma-Aldrich R129 Monoclonal Anti-Ryanodine Receptor antibody produced in mouse	Sigma-Aldrich SAB5200022 Monoclonal Anti-CACNA1D antibody produced in mouse
description clone 1A, buffered aqueous solution	description clone 2G11, ascites fluid, buffered aqueous solution	description clone 34C, ascites fluid	description clone S48A-9, 1 mg/mL, purified immunoglobulin
clone 1A, monoclonal	clone 2G11, monoclonal	clone 34C, monoclonal	clone S48A-9, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form purified immunoglobulin
species reactivity human (weakly), guinea pig, mouse, rat, rabbit	species reactivity pig, mouse, rabbit, rat, bovine, ferret, canine	species reactivity human, rat, rabbit, canine, mink, bovine, frog, fish, primate, chicken, mouse, sheep	species reactivity human, rat, mouse
Gene Information human ... CACNA1S(779) mouse ... Cacna1s(12292) rat ... Cacna1s(682930)	Gene Information mouse ... Atp4b(11945) rat ... Atp4b(24217)	Gene Information human ... RYR1(6261), RYR2(6262) mouse ... Ryr1(20190), Ryr2(20191) rat ... Ryr1(114207), Ryr2(84025)	Gene Information rat ... Cacna1d(29716)
isotype IgG1	isotype IgG1	isotype IgG1	isotype IgG2aκ

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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