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Anti-D₁ Dopamine Receptor antibody,Rat monoclonal

Name: Anti-D<SUB>1</SUB> Dopamine Receptor antibody,Rat monoclonal
Brand: SIGMA
Price: 590 EUR

clone 1-1-F11 s.E6, purified from hybridoma cell culture

Synonym(s):

Anti-DRD1

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Size/SKU	Availability	Price
100 μL	Check Cart for Availability	€ 590,00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.25

MDL number:

MFCD00282304

Conjugate:

unconjugated

Clone:

1-1-F11 s.E6, monoclonal

Application:

ICC, IHC, WB

Citations:

€ 590,00

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Properties

biological source

rat

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1-1-F11 s.E6, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

rat, monkey, human

concentration

~1 mg/mL

technique(s)

immunocytochemistry: 5-10 μg/mL using D₁ dopamine receptor transfected HEK-293T cells, immunohistochemistry: suitable, western blot: suitable

isotype

IgG2a

UniProt accession no.

P21728

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DRD1(1812)
rat ... Drd1a(24316)

Description

General description

D1 Dopamine Receptor encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases.

Monoclonal Anti-D1 Dopamine Receptor (rat IgG2a isotype) is derived from the rat hybridoma 1-1-F11 S.E6 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with recombinant fusion protein containing the C-terminal 97 amino acid of human D1 dopamine receptor. Dopamine receptors belong to the family of seven transmembrane domain G protein coupled receptors (GPCRs). Dopamine receptors are mainly localized in the striatum, limbic system, the brain cortex and the infundibulum. The D1-like family consists of the D1 and D5 receptors.

Immunogen

recombinant fusion protein containing the C-terminal 97 amino acid of human D₁ dopamine receptor.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Monoclonal Anti-D1 Dopamine Receptor antibody produced in rat has been used in:

immunohistochemistry
immunoblotting
immunocytochemistry
proximity ligation assay
co-immunoprecipitation
western blotting

Biochem/physiol Actions

D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. D1 receptors are expressed on airway smooth muscle (ASM) and regulate smooth muscle force via cAMP activation of protein kinase A. It is a potential target for therapeutic relaxation of ASM.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Legal Information

Sold under exclusive license from Emory University

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	ABN20	U3254	AB9141
Sigma-Aldrich D2944 Anti-D₁ Dopamine Receptor antibody,Rat monoclonal	Sigma-Aldrich ABN20 Anti-Dopamine D(1A) Receptor Antibody	Sigma-Aldrich U3254 Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat	Sigma-Aldrich AB9141 Anti-Dopamine Receptor D1 Antibody
species reactivity rat, monkey, human	species reactivity rat	species reactivity bovine, human, canine, mouse	species reactivity human
clone 1-1-F11 s.E6, monoclonal	clone polyclonal	clone DECMA-1, monoclonal	clone polyclonal
biological source rat	biological source rabbit	biological source rat	biological source rabbit
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form ascites fluid	antibody form affinity purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... DRD1(1812) rat ... Drd1a(24316)	Gene Information rat ... Drd1(24316)	Gene Information human ... CDH1(999) mouse ... Cdh1(12550)	Gene Information human ... DRD1(1812)

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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