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D6899

Diclofenac sodium salt

synthetic, ≥98% (TLC), Cyclooxygenase inhibitor, powder

Synonym(s):

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

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10 g

Available to ship TODAYfromMILWAUKEE

$82.40
25 g

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$194.00
100 g

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$528.00

About This Item

Empirical Formula (Hill Notation):
C14H10Cl2NNaO2
CAS Number:
15307-79-6
Molecular Weight:
318.13
NACRES:
NA.77
PubChem Substance ID:
24277712
UNSPSC Code:
12352200
EC Number:
239-346-4
MDL number:
MFCD00082251
Assay:
≥98% (TLC)
Form:
powder
Quality level:
100

$82.40

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Product Name

Diclofenac sodium salt,

biological source

synthetic

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

283-285  °C

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

originator

Novartis

storage temp.

room temp

SMILES string

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Application

Diclofenac sodium has been used:
  • to investigate its radioprotective potential in a study[1]
  • to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study[2]
  • as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
  • to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs[3]

Biochem/physiol Actions

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase.[4] Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.[1]
Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
1188800Y0001635SML0289
Diclofenac sodium salt

Sigma-Aldrich

D6899

Diclofenac sodium salt

Diclofenac sodium United States Pharmacopeia (USP) Reference Standard

USP

1188800

Diclofenac sodium

Diclofenac for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001635

Diclofenac for system suitability

Bromfenac sodium ≥98% (HPLC)

Sigma-Aldrich

SML0289

Bromfenac sodium

assay

≥98% (TLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

powder

form

-

form

-

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

solubility

-

solubility

-

solubility

H2O: ≥5 mg/mL

originator

Novartis

originator

-

originator

-

originator

-

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Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH2100
BCCD7059
BCCB7633
BCBW9128
BCBV3438

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Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

Simultaneous potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
Analytica Chimica Acta, 470, 185-194 (2002)
Amit Alok et al.
Mutation research, 755(2), 156-162 (2013-07-06)
The potential of clinical drug diclofenac sodium which is routinely used in clinics as non-steroid anti-inflammatory drugs opens a new insight in development of radioprotector. The drug has shown its potential radioprotective efficacy in clonogenic cell survival in Chinese hamster
Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase.
E C Ku et al.
Biochemical pharmacology, 24(5), 641-643 (1975-03-01)
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Global Trade Item Number

SKUGTIN
D6899-100G04061833587973
D6899-10G04061833587980
D6899-25G04061833587997

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