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Diclofenac sodium salt

Name: Diclofenac sodium salt
Brand: SIGMA
Price: 2097 MXP

synthetic, ≥98% (TLC), Cyclooxygenase inhibitor, powder

Synonym(s):

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

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Size/SKU	Availability	Price
10 g	Check Cart for Availability	MXP 2,097.00
25 g	Available to ship TODAYfromToluca	MXP 4,776.00
100 g	Available to ship TODAYfromToluca	MXP 10,376.00

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀Cl₂NNaO₂

CAS Number:

15307-79-6

Molecular Weight:

318.13

NACRES:

NA.77

PubChem Substance ID:

24277712

UNSPSC Code:

12352200

EC Number:

239-346-4

MDL number:

MFCD00082251

Assay:

≥98% (TLC)

Form:

powder

MXP 2,097.00

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Properties

Product Name

Diclofenac sodium salt,

biological source

synthetic

Quality Segment

100

assay

≥98% (TLC)

form

powder

mp

283-285 °C

solubility

methanol: 50 mg/mL, clear, colorless to faint yellow or tan

originator

Novartis

storage temp.

room temp

SMILES string

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChI key

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Description

Application

Diclofenac sodium has been used:

to investigate its radioprotective potential in a studyPMID 23827778
to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a studyPMID 18572876
as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEsPMID 26683337

Biochem/physiol Actions

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase.[1] Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.[2]

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

1 of 1

This Item	93484	1188800	S0765000
Sigma-Aldrich D6899 Diclofenac sodium salt	Supelco 93484 Diclofenac sodium salt	USP 1188800 Diclofenac sodium	S0765000 Diclofenac sodium
description -	description analytical standard	description United States Pharmacopeia (USP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard
form powder	form -	form -	form -
assay ≥98% (TLC)	assay ≥98.5% (HPLC)	assay -	assay -
Quality Level 100	Quality Level 100	Quality Level -	Quality Level -
storage temp. room temp	storage temp. -	storage temp. -	storage temp. -
solubility methanol: 50 mg/mL, clear, colorless to faint yellow or tan	solubility -	solubility -	solubility -
originator Novartis	originator -	originator -	originator -

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pictograms

GHS06,GHS08,GHS09

signalword

Danger

hcodes

H301,H361d,H372,H411

pcodes

P202 - P260 - P264 - P273 - P280 - P301 + P310

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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