Key Documents

Daidzein

Name: Daidzein
Brand: SIGMA
Price: 164 CAD

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

Synonym(s):

4′,7-Dihydroxyisoflavone, 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-3-(4-hydroxyphenyl)chromone, Isoaurostatin

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Pack Size	SKU	Availability	Price
25 mg		Please contact Customer Service for Availability	$164.00
100 mg		Please contact Customer Service for Availability	$543.00

About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₄

CAS Number:

486-66-8

Molecular Weight:

254.24

NACRES:

NA.77

PubChem Substance ID:

24278030

UNSPSC Code:

12352202

EC Number:

207-635-4

MDL number:

MFCD00016954

Beilstein/REAXYS Number:

231523

Assay:

≥98%

Form:

powder

Quality level:

200

$164.00

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Properties

Product Name

Daidzein, ≥98%, synthetic

biological source

synthetic

Quality Level

200

assay

≥98%

form

powder

mp

>290 °C

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

InChI

1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

InChI key

ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), UGT1A4(54657)
mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161)
rat ... Aldh1a2(116676)

Description

General description

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Application

Daidzein has been used:

as a control to evaluate fertility in rats
to study its effects on ovarian cancer
to simulate in vitro antioxidant activity

Biochem/physiol Actions

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.[1] Arrests cell cycle at G₁ in Swiss 3T3 cells.[2]

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Packaging

Packaged under Argon.

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Show Differences

1 of 1

This Item	16587	251600	PHL89181
Sigma-Aldrich D7802 Daidzein	Supelco 16587 Daidzein	Sigma-Aldrich 251600 Daidzein	PHL89181 Daidzein
form powder	form -	form solid	form powder
assay ≥98%	assay ≥97.0% (HPLC)	assay ≥98% (HPLC)	assay ≥95.0% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL	solubility -	solubility DMSO: 200 mg/mL	solubility -
Gene Information human ... ESR1(2099), ESR2(2100), UGT1A4(54657) mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161) rat ... Aldh1a2(116676)	Gene Information -	Gene Information -	Gene Information -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer

Chan KKL, et al.

Cancer Cell International, 18(1), 65-65 (2018)

Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells.

K Higashi et al.

Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)

An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After

Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine

Matthies A, et al.

Applied and Environmental Microbiology, 74(15), 4847-4852 (2008)

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Global Trade Item Number

SKU	GTIN
D7802-25MG	04061833588918
D7802-100MG	04061833588901

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