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D7802

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

Synonym(s):

4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin

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Pack SizeSKUAvailabilityPrice
25 mg
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$145.00
100 mg
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$474.00

About This Item

Empirical Formula (Hill Notation):
C15H10O4
CAS Number:
486-66-8
Molecular Weight:
254.24
NACRES:
NA.77
PubChem Substance ID:
24278030
UNSPSC Code:
12352202
EC Number:
207-635-4
MDL number:
MFCD00016954
Beilstein/REAXYS Number:
231523
Assay:
≥98%
Form:
powder
Quality level:
200

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Product Name

Daidzein, ≥98%, synthetic

biological source

synthetic

Quality Level

200

assay

≥98%

form

powder

mp

>290 °C

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

InChI

1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

InChI key

ZQSIJRDFPHDXIC-UHFFFAOYSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), UGT1A4(54657)
mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161)
rat ... Aldh1a2(116676)

General description

Daidzein is an isoflavone present in soy. It regulates oxidative stress, angiogenesis, cell growth and apoptosis. Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.

Application

Daidzein has been used:
  • as a control to evaluate fertility in rats
  • to study its effects on ovarian cancer
  • to simulate in vitro antioxidant activity

Biochem/physiol Actions

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.[1] Arrests cell cycle at G1 in Swiss 3T3 cells.[2]
Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Packaging

Packaged under Argon.

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This Item
16587251600PHR1858
Daidzein ≥98%, synthetic

Sigma-Aldrich

D7802

Daidzein

Daidzein analytical standard

Supelco

16587

Daidzein

Daidzein Inactive analog of Genistein.

Sigma-Aldrich

251600

Daidzein

Daidzein Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1858

Daidzein

form

powder

form

-

form

solid

form

powder

assay

≥98%

assay

≥97.0% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

300

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-10 to -25°C

solubility

DMSO: 10 mg/mL

solubility

-

solubility

DMSO: 200 mg/mL

solubility

-

mp

>290 °C

mp

-

mp

-

mp

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000520560
0000520560
0000486497
0000486516
0000486516

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Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

K Higashi et al.
Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)
An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After
N Sathyamoorthy et al.
Cancer research, 54(4), 957-961 (1994-02-15)
Epidemiological studies suggest a lowered risk of hormone-dependent cancers among vegetarians, but the basis for this association remains unclear. Vegetables and fruits contain certain compounds which can be converted to biologically active hormone-like substances, such as lignans and isoflavones, by
Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer
Chan KKL, et al.
Cancer Cell International, 18(1), 65-65 (2018)
View All Related Papers

Global Trade Item Number

SKUGTIN
D7802-25MG04061833588918
D7802-100MG04061833588901

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