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D8147

Dynorphin A porcine

≥95% (HPLC)

Synonym(s):

Dynorphin-(1-17)

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0.5 mg
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$464.00
$394.40
1 mg
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$790.00

About This Item

Empirical Formula (Hill Notation):
C99H155N31O23
CAS Number:
80448-90-4
Molecular Weight:
2147.48
NACRES:
NA.32
PubChem Substance ID:
24894194
UNSPSC Code:
51111800
MDL number:
MFCD00076351

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Quality Level

200

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P01214, P32300, P33533, P41145

storage temp.

−20°C

SMILES string

[H]N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

InChI

1S/C99H155N31O23/c1-7-55(6)81(129-86(142)66(28-18-40-112-98(107)108)118-83(139)65(27-17-39-111-97(105)106)120-88(144)70(44-54(4)5)125-89(145)71(46-56-21-9-8-10-22-56)117-79(135)52-115-78(134)51-116-82(138)61(102)45-57-31-33-59(131)34-32-57)94(150)122-67(29-19-41-113-99(109)110)95(151)130-42-20-30-75(130)93(149)121-64(26-14-16-38-101)85(141)124-69(43-53(2)3)87(143)119-63(25-13-15-37-100)84(140)126-72(47-58-50-114-62-24-12-11-23-60(58)62)90(146)128-74(49-80(136)137)92(148)127-73(48-77(104)133)91(147)123-68(96(152)153)35-36-76(103)132/h8-12,21-24,31-34,50,53-55,61,63-75,81,114,131H,7,13-20,25-30,35-49,51-52,100-102H2,1-6H3,(H2,103,132)(H2,104,133)(H,115,134)(H,116,138)(H,117,135)(H,118,139)(H,119,143)(H,120,144)(H,121,149)(H,122,150)(H,123,147)(H,124,141)(H,125,145)(H,126,140)(H,127,148)(H,128,146)(H,129,142)(H,136,137)(H,152,153)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t55-,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,81-/m0/s1

InChI key

JMNJYGMAUMANNW-FIXZTSJVSA-N

Gene Information

human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613)

Application

Dynorphin A has been used in immunohistochemistry.

Biochem/physiol Actions

Dynorphin A porcine is an opioid peptide. It is an endogenous κ-agonist that is resistant to enzymatic degradation. Dynorphin A has the ability to decrease calcium current by selectively decreasing the large inactivating (N) calcium current. It can decrease the calcium-dependent action potential duration of DRG (dorsal root ganglion) and myenteric neurons.

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Dynorphin A porcine ≥95% (HPLC)

Sigma-Aldrich

D8147

Dynorphin A porcine

Leucine Enkephalin acetate salt hydrate ≥95% (HPLC)

Sigma-Aldrich

L9133

Leucine Enkephalin acetate salt hydrate

Dynorphin A Porcine Fragment 1-13 ≥97% (HPLC)

Sigma-Aldrich

D7017

Dynorphin A Porcine Fragment 1-13

[D-Ala2]-Deltorphin II ≥97% (HPLC)

Sigma-Aldrich

T0675

[D-Ala2]-Deltorphin II

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

-

form

powder

form

powder

UniProt accession no.

P01214, P33533, P32300, P41145

UniProt accession no.

-

UniProt accession no.

P01214

UniProt accession no.

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613)

Gene Information

human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)

Gene Information

pig ... PDYN(445529)

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprd1(18386), Oprm1(18390)
rat ... Oprd1(24613), Oprm1(25601)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCR4396
SLCR4396
SLCP6380
SLCC4147
SLBZ2917

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S Zhang et al.
The Journal of pharmacology and experimental therapeutics, 286(1), 136-141 (1998-07-10)
Dynorphin A is an endogenous opioid peptide that activates the kappa opioid receptor (KOR) with high potency. Some studies also showed that the distribution and functional activity of dynorphin A are not completely correlated with those of KOR, suggesting that
S J Shuster et al.
Neuroscience, 96(2), 373-383 (2000-02-23)
The relationship between the cloned kappa opioid receptor, dynorphin, and the neurohypophysial hormones vasopressin and oxytocin was analysed in the guinea-pig hypothalamic magnocellular neurosecretory neurons. This analysis was performed in order to understand better which population of neuroendocrine neurons in
T Naqvi et al.
Peptides, 19(7), 1277-1292 (1998-10-24)
An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has yet
View All Related Papers

Global Trade Item Number

SKUGTIN
D8147-.5MG04061832676623
D8147-1MG04061826152638
D8147-.1MG04061832676616

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