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E-Cadherin/Fc Chimera from mouse

Name: E-Cadherin/Fc Chimera from mouse
Brand: SIGMA
Price: 759.9 USD
Availability: InStock

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

L-CAM, Arc-1, Cell-CAM120/80, Epithelial cadherin, Uvomorulin

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Pack Size	SKU	Availability	Price
50 μg		Available to ship TODAYfromMILWAUKEE	$894.00 $759.90

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD03456676

Form:

lyophilized powder

Assay:

>90% (SDS-PAGE)

Biological source:

mouse

Recombinant:

expressed in NSO cells

Mol wt:

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

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Properties

biological source

mouse

Quality Level

100

recombinant

expressed in NSO cells

sterility

sterile; sterile-filtered

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P09803

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... Cdh1(12550)

Description

General description

E (epithelial)-cadherin is a type I classical cadherin, which exists as a dimer. It has an ectodomain made of five extracellular cadherin-like (EC) domains, connected by conserved linker regions, which are calcium-binding in nature. It spans the membrane once, and contains a cytoplasmic region.[1] It is a glycoprotein, and in humans has a molecular weight of 120kDa. It binds to catenin and cytoskeletal protein with its C-terminal domain.[2]

Extracellular domain of mouse E-Cadherin (amino acids 1-709) fused to the carboxy-terminal 6X histidine tagged Fc region of human IgG1.

Application

E-Cadherin/Fc Chimera from mouse has been used in adhesion assays.

Biochem/physiol Actions

E (epithelial)-cadherin is involved in hemophilic cell-cell adhesion in a calcium-dependent manner. It forms adheren junctions through its ectodomains, to maintain physical contacts between adjacent cells.[1] It plays essential roles in developmental processes, tissue homeostasis and multiple diseases. In humans, this protein might be involved in the pathophysiology of ulcerative colitis. In Crohn′s diseased patients, mutations in this gene lead to a truncated or mislocalized protein product.[3] Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are the underlying processes of tumorigenesis and embryogenesis, and these involve the control of E-cadherin expression.[4]

Physical form

Lyophilized from 0.2 μm filtered solution in 20mM MES, 300mM NaCl, 1mM CaCl2.

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Show Differences

1 of 1

This Item	E0778	E0528	N6784
Sigma-Aldrich E2153 E-Cadherin/Fc Chimera from mouse	Sigma-Aldrich E0778 Ephrin-B2/Fc Chimera from mouse	Sigma-Aldrich E0528 Ephrin-A5/Fc Chimera human	Sigma-Aldrich N6784 Noggin/Fc Chimera from mouse
biological source mouse	biological source mouse	biological source human	biological source mouse
assay >90% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay >95% (SDS-PAGE)
recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) -	technique(s) -
mol wt monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing)	mol wt monomer calculated mol wt 49.6 kDa, 60-65 kDa by SDS-PAGE (reducing)	mol wt monomer calculated mol wt 48.6 kDa, 50-55 kDa by SDS-PAGE (reducing)	mol wt 55-60 kDa by SDS-PAGE (reducing), calculated mol wt 50 kDa
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
E2153-50UG	04061833602478

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