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E2153

E-Cadherin/Fc Chimera from mouse

Name: E-Cadherin/Fc Chimera from mouse
Brand: SIGMA
Price: 926.5 CAD

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonyme(s) :

L-CAM, Arc-1, Cell-CAM120/80, Epithelial cadherin, Uvomorulin

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Conditionnement	Référence	Disponibilité	Prix
50 μg		Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.	1 090,00 $ 926,50 $

A propos de cet article

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD03456676

Form:

lyophilized powder

Assay:

>90% (SDS-PAGE)

Biological source:

mouse

Recombinant:

expressed in NSO cells

Mol wt:

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

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Propriétés

biological source

mouse

Quality Level

100

recombinant

expressed in NSO cells

sterility

sterile; sterile-filtered

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P09803

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... Cdh1(12550)

Description

General description

E (epithelial)-cadherin is a type I classical cadherin, which exists as a dimer. It has an ectodomain made of five extracellular cadherin-like (EC) domains, connected by conserved linker regions, which are calcium-binding in nature. It spans the membrane once, and contains a cytoplasmic region.[1] It is a glycoprotein, and in humans has a molecular weight of 120kDa. It binds to catenin and cytoskeletal protein with its C-terminal domain.[2]

Extracellular domain of mouse E-Cadherin (amino acids 1-709) fused to the carboxy-terminal 6X histidine tagged Fc region of human IgG1.

Application

E-Cadherin/Fc Chimera from mouse has been used in adhesion assays.

Biochem/physiol Actions

E (epithelial)-cadherin is involved in hemophilic cell-cell adhesion in a calcium-dependent manner. It forms adheren junctions through its ectodomains, to maintain physical contacts between adjacent cells.[1] It plays essential roles in developmental processes, tissue homeostasis and multiple diseases. In humans, this protein might be involved in the pathophysiology of ulcerative colitis. In Crohn′s diseased patients, mutations in this gene lead to a truncated or mislocalized protein product.[3] Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are the underlying processes of tumorigenesis and embryogenesis, and these involve the control of E-cadherin expression.[4]

Physical form

Lyophilized from 0.2 μm filtered solution in 20mM MES, 300mM NaCl, 1mM CaCl2.

Comparer avec des articles similaires

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1 of 1

Cet article	E0778	O8137	E9902
Sigma-Aldrich E2153 E-Cadherin/Fc Chimera from mouse	Sigma-Aldrich E0778 Ephrin-B2/Fc Chimera from mouse	Sigma-Aldrich O8137 Osteoprotegerin/Fc Chimera from mouse	Sigma-Aldrich E9902 Ephrin-A1/Fc Chimera from mouse
recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells
assay >90% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay >90% (SDS-PAGE)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) -	technique(s) -
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
mol wt monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing)	mol wt monomer calculated mol wt 49.6 kDa, 60-65 kDa by SDS-PAGE (reducing)	mol wt 100 kDa by SDS-PAGE (reducing), calculated mol wt 70.9 kDa	mol wt monomer calculated mol wt 46.8 kDa, 50-55 kDa by SDS-PAGE (reducing)

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Contenu apparenté

Data Sheet - E2153

Instructions

Xenopus δ-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases.

Gu D, et al.

Journal of Cell Science, 122(22), 4049-4061 (2009)

Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion.

Ying Li et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16462-16467 (2013-09-27)

Epithelial cadherin (E-cadherin), a member of the classical cadherin family, mediates calcium-dependent homophilic cell-cell adhesion. Crystal structures of classical cadherins reveal an adhesive dimer interface featuring reciprocal exchange of N-terminal β-strands between two protomers. Previous work has identified a putative

Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases.

Dongmin Gu et al.

Journal of cell science, 122(Pt 22), 4049-4061 (2009-10-22)

Catenins of the p120 subclass display an array of intracellular localizations and functions. Although the genetic knockout of mouse delta-catenin results in mild cognitive dysfunction, we found severe effects of its depletion in Xenopus. delta-catenin in Xenopus is transcribed as

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Numéro d'article de commerce international

Référence	GTIN
E2153-50UG	04061833602478

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