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E2153

E-Cadherin/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonyme(s) :

L-CAM, Arc-1, Cell-CAM120/80, Epithelial cadherin, Uvomorulin

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À vous/RéférenceDisponibilitéPrix
50 μg
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738.00 CHF
627.30 CHF

A propos de cet article

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD03456676
Form:
lyophilized powder
Assay:
>90% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in NSO cells
Mol wt:
monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

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biological source

mouse

Quality Segment

100

recombinant

expressed in NSO cells

sterility

sterile; sterile-filtered

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing), calculated mol wt 88.2 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P09803

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... Cdh1(12550)

General description

E (epithelial)-cadherin is a type I classical cadherin, which exists as a dimer. It has an ectodomain made of five extracellular cadherin-like (EC) domains, connected by conserved linker regions, which are calcium-binding in nature. It spans the membrane once, and contains a cytoplasmic region.[1] It is a glycoprotein, and in humans has a molecular weight of 120kDa. It binds to catenin and cytoskeletal protein with its C-terminal domain.[2]
Extracellular domain of mouse E-Cadherin (amino acids 1-709) fused to the carboxy-terminal 6X histidine tagged Fc region of human IgG1.

Application

E-Cadherin/Fc Chimera from mouse has been used in adhesion assays.

Biochem/physiol Actions

E (epithelial)-cadherin is involved in hemophilic cell-cell adhesion in a calcium-dependent manner. It forms adheren junctions through its ectodomains, to maintain physical contacts between adjacent cells.[1] It plays essential roles in developmental processes, tissue homeostasis and multiple diseases. In humans, this protein might be involved in the pathophysiology of ulcerative colitis. In Crohn′s diseased patients, mutations in this gene lead to a truncated or mislocalized protein product.[3] Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are the underlying processes of tumorigenesis and embryogenesis, and these involve the control of E-cadherin expression.[4]

Physical form

Lyophilized from 0.2 μm filtered solution in 20mM MES, 300mM NaCl, 1mM CaCl2.

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Cet article
E9902N6784E9402
E-Cadherin/Fc Chimera from mouse >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

E2153

E-Cadherin/Fc Chimera from mouse

Ephrin-A1/Fc Chimera from mouse >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

E9902

Ephrin-A1/Fc Chimera from mouse

Noggin/Fc Chimera from mouse >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

N6784

Noggin/Fc Chimera from mouse

EphB2/Fc Chimera from mouse >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

E9402

EphB2/Fc Chimera from mouse

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

ligand binding assay: suitable

assay

>90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>90% (SDS-PAGE)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

mol wt

monomer calculated mol wt 88.2 kDa, ~120 kDa by SDS-PAGE (reducing)

mol wt

monomer calculated mol wt 46.8 kDa, 50-55 kDa by SDS-PAGE (reducing)

mol wt

55-60 kDa by SDS-PAGE (reducing), calculated mol wt 50 kDa

mol wt

monomer calculated mol wt 85.3 kDa, 100-110 kDa by SDS-PAGE (reducing)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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