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E3763
Resorufin ethyl ether
≥98% (TLC), CXPIA1/2 substrate, powder
Synonyme(s) :
7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin
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| À vous/Référence | Disponibilité | Prix |
|---|---|---|
1 mg | Vérifier la disponibilité des articles du panier | 132.00 CHF |
5 mg | Vérifier la disponibilité des articles du panier | 317.00 CHF |
A propos de cet article
Formule empirique (notation de Hill) :
C14H11NO3
Numéro CAS:
Poids moléculaire :
241.24
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
225973
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Resorufin ethyl ether, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
storage condition
(Tightly closed. Dry)
technique(s)
activity assay: suitable
color
orange to red
mp
223-225 °C (lit.)
solubility
chloroform: 9.80-10.20 mg/mL, clear, orange
suitability
suitable for fluorescence
storage temp.
−20°C
SMILES string
CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
InChI
1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
InChI key
ZOSYTBPPLWBBKM-UHFFFAOYSA-N
General description
Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2
Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.[1]
Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.
Research area: Cell Signaling
Research area: Cell Signaling
Application
Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors.[2] It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).[3]
1 of 1
Cet article | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥95% (UV) | assay ≥98.0% (HPLC) | assay ≥98% (TLC) |
| solubility chloroform: 9.80-10.20 mg/mL, clear, orange | solubility DMF: soluble, DMSO: soluble, alcohols: soluble | solubility dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange | solubility acetonitrile: 0.95- 1.05 mg/mL, clear, orange |
| technique(s) activity assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| suitability suitable for fluorescence | suitability suitable for fluorescence | suitability - | suitability - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder | form solid | form powder | form powder |
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Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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