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E3888

[D-Pen2,5]-Enkephalin hydrate

≥95% (HPLC)

Synonym(s):

DPDPE

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1 mg

Available to ship TODAYfromMILWAUKEE

$174.00
$174.00

About This Item

Empirical Formula (Hill Notation):
C30H39N5O7S2 · xH2O
Molecular Weight:
645.79 (anhydrous basis)
NACRES:
NA.32
PubChem Substance ID:
329799055
UNSPSC Code:
12352209
MDL number:
MFCD00076430

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Quality Segment

200

assay

≥95% (HPLC)

storage temp.

−20°C

SMILES string

CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O

InChI

1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1

InChI key

MCMMCRYPQBNCPH-WMIMKTLMSA-N

General description

[D-Pen2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist.PMID 8912400 Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.PMID 2160532

Application

[D-Pen2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents.[1] It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).[2]

Biochem/physiol Actions

Antinociceptive activity mediated through the δ1 receptor while the modulatory activity is mediated through the δ2 receptor. Tritiated [D-Pen2,5]-enkephalin is used as a δ1 ligand.

Other Notes

Lyophilized from 0.1% TFA in H2O

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E7131M6638L9133
[D-Pen2,5]-Enkephalin hydrate ≥95% (HPLC)

Sigma-Aldrich

E3888

[D-Pen2,5]-Enkephalin hydrate

[D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC)

Sigma-Aldrich

E7131

[D-Ala2, D-Leu5]-Enkephalin acetate salt

[Met5]Enkephalin acetate salt hydrate ≥95.0% (HPLC), powder

Sigma-Aldrich

M6638

[Met5]Enkephalin acetate salt hydrate

Leucine Enkephalin acetate salt hydrate ≥95% (HPLC)

Sigma-Aldrich

L9133

Leucine Enkephalin acetate salt hydrate

description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥95.0% (HPLC), powder

description

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95.0% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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