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E6910

Pioglitazone hydrochloride

Name: Pioglitazone hydrochloride
Brand: SIGMA
Price: 86.6 EUR

≥98% (HPLC), powder, hepatic gluconeogenesis blocker

Sinonimo/i:

5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride

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A voi/SKU	Disponibilità	Prezzo
10 mg	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	86,60 €
50 mg	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	334,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₉H₂₀N₂O₃S · HCl

Numero CAS:

112529-15-4

Peso molecolare:

392.90

UNSPSC Code:

41106305

PubChem Substance ID:

329799001

NACRES:

NA.77

MDL number:

MFCD04975446

Assay:

≥98% (HPLC)

Form:

powder

86,60 €

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Proprietà

Nome del prodotto

Pioglitazone hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥10 mg/mL

originator

Takeda

storage temp.

room temp

SMILES string

Cl.CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1

InChI

1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H

InChI key

GHUUBYQTCDQWRA-UHFFFAOYSA-N

Gene Information

human ... PPARG(5468)

Descrizione

General description

Pioglitazone hydrochloride consists of poly-morphs, form I and form II. It is an oral antidiabetic agent, that is a member of the thiazolidinedione group.

Application

Pioglitazone hydrochloride has been used:

to administer to mice model and treated the hepatoma cell line to study its effect on regulating insulin-degrading enzyme (IDE) in diet-induced obese (DIO) C57BL/6 mice
in drug preparation to analyze its effects on shortening and calcium transport in ventricular myocytes from the Goto-Kakizaki (GK) type 2 diabetic rat
to treat HepG2 cells with peroxisome proliferator-activated receptor γ (PPARγ) agonists to examine its effect on TOMM40-, APOE- and APOC1-mRNA levels

Biochem/physiol Actions

Pioglitazone hydrochloride is a PPARγ agonist and thiazolidinedione (TZD) anti-diabetic.

Pioglitazone hydrochloride is a PPARγ agonist and thiazolidinedione (TZD) anti-diabetic. Pioglitazone is a selective agonist of the nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ) and to a lesser extent PPAR-α.

Pioglitazone hydrochloride is usually used to treat type-II diabetes. It has the ability to block hepatic gluconeogenesis.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the AMPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo	PHR1632	Y0001520	Y0001519
Sigma-Aldrich E6910 Pioglitazone hydrochloride	Supelco PHR1632 Pioglitazone hydrochloride	Y0001520 Pioglitazone hydrochloride	Y0001519 Pioglitazone for system suitability
form powder	form -	form -	form -
assay ≥98% (HPLC)	assay -	assay -	assay -
storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥10 mg/mL	solubility -	solubility -	solubility -
originator Takeda	originator -	originator -	originator -
color white to off-white	color -	color -	color -

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c