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F100

Fluspirilene

Synonym(s):

8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218

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Pack SizeSKUAvailabilityPrice
10 mg
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$191.00
50 mg
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$762.00

About This Item

Empirical Formula (Hill Notation):
C29H31F2N3O
CAS Number:
1841-19-6
Molecular Weight:
475.57
NACRES:
NA.77
PubChem Substance ID:
24277915
UNSPSC Code:
12352200
EC Number:
217-418-6
MDL number:
MFCD00055137
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200

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assay

≥98% (HPLC)

Quality Level

200

form

solid

color

white

solubility

DMSO: ≥20 mg/mL, H2O: insoluble, ethanol: soluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5

InChI

1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

InChI key

QOYHHIBFXOOADH-UHFFFAOYSA-N

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1 of 1

This Item
P3371JN0006L9668
Fluspirilene

Sigma-Aldrich

F100

Fluspirilene

Penfluridol ≥97% (HPLC), powder

Sigma-Aldrich

P3371

Penfluridol

Draflazine ≥98% (HPLC)

Sigma-Aldrich

JN0006

Draflazine

Lidoflazine ≥98% (HPLC), powder

Sigma-Aldrich

L9668

Lidoflazine

form

solid

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

100

originator

Johnson & Johnson

originator

Johnson & Johnson

originator

-

originator

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL, ethanol: soluble, H2O: insoluble

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

Application

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).
Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.

Biochem/physiol Actions

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.
Fluspirilene is a dopamine receptor antagonist. It also acts as a calcium channel blocker. Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties. It exhibits therapeutic effects against glioblastoma and Schizophrenia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000245411
0000245411
0000144674
0000101994

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Su-Jane Wang
Synapse (New York, N.Y.), 44(1), 36-41 (2002-02-14)
Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of this study was to investigate
Christine Zalejski et al.
Plant physiology, 141(4), 1555-1562 (2006-06-13)
Diacylglycerol pyrophosphate (DGPP) was recently shown to be a possible intermediate in abscisic acid (ABA) signaling. In this study, reverse transcription-PCR of ABA up-regulated genes was used to evaluate the ability of DGPP to trigger gene expression in Arabidopsis (Arabidopsis
Depot fluspirilene for schizophrenia
Abhijnhan A, et al.
Cochrane database of systematic reviews (Online), 8(1), 111728-111728 (2007)
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
Dong Y, et al.
Oncotarget, 8(67), 111728-111728 (2017)
Qin Cao et al.
Nature chemistry (2018-10-10)
Inhibiting the interaction between amyloid-β (Aβ) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer's disease. Supporting this approach, Alzheimer's-like symptoms are reduced in mouse models following genetic depletion of the LilrB2
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Global Trade Item Number

SKUGTIN
F100-50MG04061832090740
F100-10MG04061832090733

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