Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

F100

Fluspirilene

Synonym(s):

8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
10 mg
0 left in stock
$191.00
50 mg
0 left in stock
$762.00

About This Item

Empirical Formula (Hill Notation):
C29H31F2N3O
CAS Number:
1841-19-6
Molecular Weight:
475.57
NACRES:
NA.77
PubChem Substance ID:
24277915
UNSPSC Code:
12352200
EC Number:
217-418-6
MDL number:
MFCD00055137
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200

$191.00

0 left in stock
​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥98% (HPLC)

Quality Level

200

form

solid

color

white

solubility

DMSO: ≥20 mg/mL, H2O: insoluble, ethanol: soluble

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5

InChI

1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

InChI key

QOYHHIBFXOOADH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Application

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).
Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.

Biochem/physiol Actions

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.
Fluspirilene is a dopamine receptor antagonist. It also acts as a calcium channel blocker. Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties. It exhibits therapeutic effects against glioblastoma and Schizophrenia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
P3371JN0006L9668
Fluspirilene

Sigma-Aldrich

F100

Fluspirilene

Penfluridol ≥97% (HPLC), powder

Sigma-Aldrich

P3371

Penfluridol

Draflazine ≥98% (HPLC)

Sigma-Aldrich

JN0006

Draflazine

Lidoflazine ≥98% (HPLC), powder

Sigma-Aldrich

L9668

Lidoflazine

form

solid

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL, ethanol: soluble, H2O: insoluble

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

color

white

color

white

color

white to beige

color

white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000245411
0000245411
0000144674
0000101994

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Christine Zalejski et al.
Plant physiology, 141(4), 1555-1562 (2006-06-13)
Diacylglycerol pyrophosphate (DGPP) was recently shown to be a possible intermediate in abscisic acid (ABA) signaling. In this study, reverse transcription-PCR of ABA up-regulated genes was used to evaluate the ability of DGPP to trigger gene expression in Arabidopsis (Arabidopsis
Su-Jane Wang
Synapse (New York, N.Y.), 44(1), 36-41 (2002-02-14)
Fluspirilene, a neuroleptic drug which is used clinically to treat schizophrenic patients, is a dopamine D2 receptor antagonist. Besides its well-known actions on the dopamine receptors, fluspirilene also displays calcium channel-blocking activity. The aim of this study was to investigate
In silico identification and in vitro and in vivo validation of anti-psychotic drug fluspirilene as a potential CDK2 inhibitor and a candidate anti-cancer drug
Shi XN, et al.
PLoS ONE, 10(7), e1753-e1753 (2015)
View All Related Papers

Global Trade Item Number

SKUGTIN
F100-50MG04061832090740
F100-10MG04061832090733

Questions

Reviews

No rating value

Active Filters