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Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

Name: Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit
Brand: SIGMA
Price: 209.1 USD
Availability: InStock

fractionated antiserum, lyophilized powder

Synonym(s):

Anti-FGF2, Anti-bFGF

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Size/SKU	Availability	Price
0.1 mL	Check Cart for Availability	$246.00 $209.10

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01322020

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IHC (p), WB

Citations:

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, bovine, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1:1,000

impurities

endotoxin, tested

UniProt accession no.

P09038

application(s)

research pathology

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

bovine ... FGF2(281161)
human ... FGF2(2247)
rat ... Fgf2(54250)

Description

General description

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Immunogen

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Application

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:

immunohistochemistry
immunostaining
immunoblotting

Biochem/physiol Actions

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	F6162	SAB5700986	SAB2108135
$Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit fractionated antiserum, lyophilized powder$ Sigma-Aldrich F3393 Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit	Sigma-Aldrich F6162 Anti-Fibroblast Growth Factor-Basic antibody, Mouse monoclonal	Sigma-Aldrich SAB5700986 Anti- FGF2 antibody produced in rabbit	Sigma-Aldrich SAB2108135 Anti-FGF2 antibody produced in rabbit
description fractionated antiserum, lyophilized powder	description clone FB-8, purified from hybridoma cell culture	description -	description affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
antibody form fractionated antiserum	antibody form purified immunoglobulin	antibody form -	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
form lyophilized powder	form buffered aqueous solution	form liquid	form buffered aqueous solution
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1:1,000	technique(s) indirect ELISA: suitable, western blot: suitable, radioimmunoassay: suitable, neutralization: 5 μg/mL using 1 unit recombinant human FGF2 in mouse 3T3 cells, dot blot: suitable	technique(s) western blot: 1:500-1:2000, immunohistochemistry: 1:50-1:200	technique(s) immunoblotting: suitable, immunohistochemistry: suitable

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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