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F6755

Fibrinogen from rat plasma

60-80% protein (≥60% of protein is clottable)

Synonyme(s) :

Factor I

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ConditionnementRéférenceDisponibilitéPrix
25 mg
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711,00 €
100 mg
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2 400,00 €

A propos de cet article

Numéro CAS:
9001-32-5
UNSPSC Code:
12352202
EC Number:
232-598-6
NACRES:
NA.61
MDL number:
MFCD00131060
Form:
powder
Biological source:
rat plasma
Mol wt:
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

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biological source

rat plasma

Quality Segment

200

form

powder

quality

60-80% protein (≥60% of protein is clottable)

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

concentration

60-80% (biuret)

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

UniProt accession no.

P02680, P06399, P14480

storage temp.

−20°C

Gene Information

rat ... Fga(361969), Fgb(24366), Fgg(24367)

Application

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).
Fibrinogen from rat plasma has been used:
  • in the preparation of growth factor solutions[1]
  • to apply on discontinuous SDS-polyacrylamide gels for the detection of IgG (immunoglobulins) type antibodies by immunoblot analysis
  • to mix with cell suspension to form a clot and retain the cells for avoiding its dispersion during transplantation

Biochem/physiol Actions

Acute phase protein that is part of the coagulation cascade of proteins.
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

Analysis Note

Contains ~12% sodium citrate and ~18% sodium chloride.
Protein determined by biuret.

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Cet article
F3879F4883F8630
Fibrinogen from rat plasma 60-80% protein (≥60% of protein is clottable)

Sigma-Aldrich

F6755

Fibrinogen from rat plasma

Fibrinogen from human plasma 50-70% protein (≥80% of protein is clottable)

Sigma-Aldrich

F3879

Fibrinogen from human plasma

Fibrinogen from human plasma 35-65% protein (≥90% of protein is clottable).

Sigma-Aldrich

F4883

Fibrinogen from human plasma

Fibrinogen from bovine plasma Type I-S, 65-85% protein (≥75% of protein is clottable)

Sigma-Aldrich

F8630

Fibrinogen from bovine plasma

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

technique(s)

ELISA: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

biological source

rat plasma

biological source

human plasma

biological source

human plasma

biological source

bovine plasma

concentration

60-80% (biuret)

concentration

50-70% protein (biuret)

concentration

35-65% protein (biuret)

concentration

65-85% (biuret)

form

powder

form

powder

form

powder

form

powder

mol wt

α-chain 63.5 kDa, γ chain 47 kDa (about 4% carbohydrate content), β-chain 56 kDa, soluble dimer 340 kDa

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

UniProt accession no.

P02680, P14480, P06399

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02672, P02676, P12799

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000560361
0000542190
0000512974
0000512976
0000512976

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Numéro d'article de commerce international

RéférenceGTIN
F6755-25MG04061833261774
F6755-100MG04061833261767

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