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F6755

Fibrinogen from rat plasma

60-80% protein (≥60% of protein is clottable)

Synonym(s):

Factor I

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25 mg

Available to ship TODAYfromMILWAUKEE

$1,010.00
100 mg

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About This Item

CAS Number:
9001-32-5
UNSPSC Code:
12352202
EC Number:
232-598-6
NACRES:
NA.61
MDL number:
MFCD00131060
Form:
powder
Biological source:
rat plasma
Mol wt:
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

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biological source

rat plasma

Quality Segment

200

form

powder

quality

60-80% protein (≥60% of protein is clottable)

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

concentration

60-80% (biuret)

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

UniProt accession no.

P02680, P06399, P14480

storage temp.

−20°C

Gene Information

rat ... Fga(361969), Fgb(24366), Fgg(24367)

Application

Fibrinogen from rat plasma has been used:
  • in the preparation of growth factor solutions
  • to apply on discontinuous SDS-polyacrylamide gels for the detection of IgG (immunoglobulins) type antibodies by immunoblot analysis
  • to mix with cell suspension to form a clot and retain the cells for avoiding its dispersion during transplantation

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).

Biochem/physiol Actions

Acute phase protein that is part of the coagulation cascade of proteins.
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

Analysis Note

Contains ~12% sodium citrate and ~18% sodium chloride.
Protein determined by biuret.

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341576M341573341578
Fibrinogen from rat plasma 60-80% protein (≥60% of protein is clottable)

Sigma-Aldrich

F6755

Fibrinogen from rat plasma

Fibrinogen, Human Plasma Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.

Sigma-Aldrich

341576M

Fibrinogen, Human Plasma

Fibrinogen, Bovine Plasma Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains mpre than 95% clottable protein.

Sigma-Aldrich

341573

Fibrinogen, Bovine Plasma

Fibrinogen, Plasminogen-Depleted, Human Plasma Plasminogen-Depleted fibrinogen is a native fibrinogen from which plasminogen is depleted using a Lys-agarose column. Contains ≥ 95% clottable proteins.

Sigma-Aldrich

341578

Fibrinogen, Plasminogen-Depleted, Human Plasma

description

60-80% protein (≥60% of protein is clottable)

description

Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein.

description

Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains mpre than 95% clottable protein.

description

Plasminogen-Depleted fibrinogen is a native fibrinogen from which plasminogen is depleted using a Lys-agarose column. Contains ≥ 95% clottable proteins.

biological source

rat plasma

biological source

human plasma

biological source

-

biological source

human plasma

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

technique(s)

-

technique(s)

-

technique(s)

-

concentration

60-80% (biuret)

concentration

-

concentration

-

concentration

-

mol wt

α-chain 63.5 kDa, γ chain 47 kDa (about 4% carbohydrate content), β-chain 56 kDa, soluble dimer 340 kDa

mol wt

-

mol wt

-

mol wt

-

form

powder

form

lyophilized

form

lyophilized

form

lyophilized

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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