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F6755

Fibrinogen from rat plasma

60-80% protein (≥60% of protein is clottable)

Synonym(s):

Factor I

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Size/SKUAvailabilityPrice
25 mg

Available to ship onSeptember 29, 2026fromMILWAUKEE

$1,050.00
100 mg

Available to ship onSeptember 29, 2026fromMILWAUKEE

$3,250.00

About This Item

CAS Number:
9001-32-5
UNSPSC Code:
12352202
EC Number:
232-598-6
NACRES:
NA.61
MDL number:
MFCD00131060
Form:
powder
Biological source:
rat plasma
Mol wt:
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

$1,050.00

Available to ship onSeptember 29, 2026Details

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biological source

rat plasma

Quality Segment

form

powder

quality

60-80% protein (≥60% of protein is clottable)

mol wt

α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa

concentration

60-80% (biuret)

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

Application

Fibrinogen from rat plasma has been used:
  • in the preparation of growth factor solutions
  • to apply on discontinuous SDS-polyacrylamide gels for the detection of IgG (immunoglobulins) type antibodies by immunoblot analysis
  • to mix with cell suspension to form a clot and retain the cells for avoiding its dispersion during transplantation

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).

Biochem/physiol Actions

Acute phase protein that is part of the coagulation cascade of proteins.
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

Analysis Note

Contains ~12% sodium citrate and ~18% sodium chloride.
Protein determined by biuret.

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Fibrinogen from rat plasma 60-80% protein (≥60% of protein is clottable)

Sigma-Aldrich

F6755

Fibrinogen from rat plasma

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Sigma-Aldrich

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Sigma-Aldrich

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Fibrinogen, Fragment D, Human Plasma Fibrinogen fragment D is a thermolabile native human plasma protein prepared by digestion of purified fibrinogen followed by preparative electrophoresis.

Sigma-Aldrich

341600

Fibrinogen, Fragment D, Human Plasma

description

60-80% protein (≥60% of protein is clottable)

description

50-70% protein (≥80% of protein is clottable)

description

Type I-S, 65-85% protein (≥75% of protein is clottable)

description

Fibrinogen fragment D is a thermolabile native human plasma protein prepared by digestion of purified fibrinogen followed by preparative electrophoresis.

technique(s)

immunoblotting: suitable, cell culture | mammalian: suitable

technique(s)

ELISA: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

biological source

rat plasma

biological source

human plasma

biological source

bovine plasma

biological source

-

concentration

60-80% (biuret)

concentration

50-70% protein (biuret)

concentration

65-85% (biuret)

concentration

-

form

powder

form

powder

form

powder

form

lyophilized

mol wt

soluble dimer 340 kDa, α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content)

mol wt

soluble dimer 340 kDa, β-chain 56 kDa, α-chain 63.5 kDa, γ chain 47 kDa (about 4% carbohydrate content)

mol wt

α-chain 63.5 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa, β-chain 56 kDa

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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