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MilliporeSigma

341600

Fibrinogen, Fragment D, Human Plasma

Fibrinogen fragment D is a thermolabile native human plasma protein prepared by digestion of purified fibrinogen followed by preparative electrophoresis.

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200 μG

$320.00

$320.00


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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

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Quality Level

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤1% Fragment E

solubility

sterile distilled water: 200 μg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
341573F9911F0287
form

lyophilized

form

lyophilized

form

lyophilized powder

form

lyophilized powder

storage condition

OK to freeze

storage condition

OK to freeze

storage condition

-

storage condition

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

wet ice

shipped in

ambient

shipped in

ambient

impurities

≤1% Fragment E

impurities

-

impurities

HIV and HBsAg, source material tested negative, Small proteolytic fragments, may contain traces

impurities

HIV and HBsAg, source material tested negative, Small proteolytic fragments, may contain traces

solubility

sterile distilled water: 200 μg/mL

solubility

sterile distilled water: soluble

solubility

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

solubility

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

General description

Native fibrinogen fragment D from human plasma prepared by plasmin digestion of purified fibrinogen followed by preparative electrophoresis. Thermolabile fragment. Complete proteolysis of a single fibrinogen molecule produces two D and one E fragments. Fragment D has been shown to increase endothelial monolayer permeability and to decrease polymorphonuclear leukocyte adhesion to endothelial cells. The D and E fragments have no common antigenic determinants; therefore, no cross-reactivity occurs.

Physical form

Lyophilized from 400 mM glycine, 150 mM NaCl.

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 4 h at 20°C or for up to 8 h at 4°C or for up to 3 months at -70°C.

Analysis Note

single band by SDS-PAGE

Other Notes

Spraggon, G., et al. 1997. Nature 389, 455.
Stirk, C.M., et al. 1993. Atherosclerosis103, 159.
Vogel, P., et al. 1993. Eur. Surg. Res.25, 83.
Azpiazu, I., and Chapman, D. 1992. Biochim. Biophys. Acta1119, 268.
Thompson, W.D., et al. 1992. J. Pathol.168, 47.
Fisher, E.G., et al. 1991. Haemostasis21, 141.
Ge, M., et al. 1991. Am. J. Physiol.261, L283.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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