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Anti-Granulocyte-Macrophage Colony Stimulating Factor antibody produced in goat

Name: Anti-Granulocyte-Macrophage Colony Stimulating Factor antibody produced in goat
Brand: SIGMA
Price: 611 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

GM-CSF, MGC131935, MGC138897, molgramostin, sargramostim

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Size/SKU	Availability	Price
0.1 mg	Available to ship TODAYfromMILWAUKEE	$611.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD02096490

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$611.00

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Properties

biological source

goat

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

western blot: 0.1 μg/mL

UniProt accession no.

P48750

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CSF2(1437)
mouse ... Csf2(12981)
rat ... Csf2(116630)

Description

General description

GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity. It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines. The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha -helices. Mature rat GM-CSF shares 56-69% amino acid sequence identity with canine, feline, human, mouse, and porcine GM-CSF. GM-CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5. In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha. Rat GM-CSF is active on mouse cells, although mouse GM-CSF is only weakly active on rat cells.

Immunogen

Purified recombinant rat GM-CSF expressed in E. coli.

Biochem/physiol Actions

Detects rat GM-CSF in direct ELISAs and Western blot. In direct ELISAs, approximately 100% cross-reactivity with recombinant feline GM-CSF and recombinant porcine GM-CSF is observed, approximately 30% cross-reactivity with recombinant mouse GM-CSF, recombinant canine GM-CSF and recombinant human GM-CSF is observed.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose

Preparation Note

Reconstitute at 0.2 mg/mL in sterile PBS.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	G5421	SAB1403704	SRP3050
Sigma-Aldrich G0907 Anti-Granulocyte-Macrophage Colony Stimulating Factor antibody produced in goat	Sigma-Aldrich G5421 Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in rat	Sigma-Aldrich SAB1403704 Monoclonal Anti-CSF2, (C-terminal) antibody produced in mouse	Sigma-Aldrich SRP3050 Granulocyte-Macrophage Colony-Stimulating Factor human
description affinity isolated antibody, lyophilized powder	description clone 67604, purified immunoglobulin, lyophilized powder	description clone 1D6, purified immunoglobulin, buffered aqueous solution	description GM-CSF, Animal-component free, recombinant, expressed in E. coli, suitable for cell culture
biological source goat	biological source rat	biological source mouse	biological source human
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
clone polyclonal	clone 67604, monoclonal	clone 1D6, monoclonal	clone -
Gene Information human ... CSF2(1437) mouse ... Csf2(12981) rat ... Csf2(116630)	Gene Information mouse ... Csf3(12985)	Gene Information human ... CSF2(1437)	Gene Information human ... CSF2(1437)

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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