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Monoclonal Anti-β-COP antibody produced in mouse

Name: Monoclonal Anti-β-COP antibody produced in mouse
Brand: SIGMA
Price: 525 USD
Availability: InStock

clone M3A5, ascites fluid

Synonym(s):

Anti-BARMACS, Anti-COPB

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromMILWAUKEE	$525.00
0.2 mL	Available to ship TODAYfromMILWAUKEE	$718.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164606

Conjugate:

unconjugated

Clone:

M3A5, monoclonal

Application:

ICC, IF, IP

Citations:

$525.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

M3A5, monoclonal

contains

15 mM sodium azide

species reactivity

monkey, human, chicken, goose, rabbit, canine, bovine, kangaroo rat, rat, hamster

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect immunofluorescence: 1:20 using cultured Chinese hamster ovary (CHO) cells

isotype

IgG1

UniProt accession no.

P53618

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COPB1(1315)
rat ... Copb1(114023)

Description

General description

Monoclonal Anti- β-COP (mouse IgG1 isotype) is derived from the M3A5 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. COPs (coatomer proteins) have a molar mass of 110 kDa and its primary structure is homologous to the β-adaptin component of clathrin-coated vesicles.

The coatomer (approx. 550kDa) consists of proteins designated α-, β-, γ-, and δ-COP, together with substoichiometric amounts of several other proteins.

Immunogen

microtubule-associated protein from goose brain.

Application

Monoclonal Anti-β-COP antibody produced in mouse has been used:

for the localization of β-COP using immunoprecipitation
in immunocytochemistry
in immunoblotting
with other antibodies to Golgi proteins to study the role and relationships of this protein in the cell

Biochem/physiol Actions

COPs (coatomer proteins) are transiently attached to the vesicles involved in transport within the Golgi complex and possibly between the rough ER and Golgi complex.

The antibody recognizes an epitope shared by β-COP (110 kDa) found in most tissue culture lines, and by a doublet of brain microtubule-associated protein (MAP2, 270-300 kDa). The antibody stains a reticular structure in the perinuclear area of non-neuronal cells (the periphery of Golgi complex and a population of coatomers scattered throughout the cytoplasm) in tissues from different species and cell processes, as well as cell bodies in chicken brain neuronal cells. It has been used for studies on the effects of various agents that influence energy status, disrupt the Golgi complex, or alter the activity of G-proteins or small GTP-binding proteins on the cellular localization of β-COP. The antibody may be used for the immunoaffinity purification of the protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	G6160	SAB4200720	C7207
Sigma-Aldrich G2279 Monoclonal Anti-β-COP antibody produced in mouse	Sigma-Aldrich G6160 Monoclonal Anti-β-COP antibody produced in mouse	Sigma-Aldrich SAB4200720 Anti-β-Catenin antibody, Mouse monoclonal	Sigma-Aldrich C7207 Monoclonal Anti-β-Catenin antibody produced in mouse
description clone M3A5, ascites fluid	description clone maD, ascites fluid	description clone 15B8, purified from hybridoma cell culture	description clone 15B8, ascites fluid
clone M3A5, monoclonal	clone maD, monoclonal	clone 15B8, monoclonal	clone 15B8, monoclonal
species reactivity monkey, human, chicken, goose, rabbit, canine, bovine, kangaroo rat, rat, hamster	species reactivity human, rat, hamster, monkey	species reactivity chicken, mouse, human, rat, monkey, hamster, bovine, canine	species reactivity chicken, bovine, human, canine
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form ascites fluid
Gene Information human ... COPB1(1315) rat ... Copb1(114023)	Gene Information human ... COPB1(1315) rat ... Copb1(114023)	Gene Information human ... CTNNB1(1499) mouse ... Ctnnb1(12387) rat ... Ctnnb1(84353)	Gene Information human ... CTNNB1(1499)

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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