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G5170

Galectin-3 human

recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

CBP 35, Carbohydrate-binding protein 35, Gal-3, Galactose-specific lectin 3, Galactoside-binding protein

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Size/SKUAvailabilityPrice
100 μg
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$778.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
lyophilized powder
Recombinant:
expressed in E. coli

$778.00


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recombinant

expressed in E. coli

Quality Segment

form

lyophilized powder

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... LGALS3(3958)

General description

Galectin-3 protein comprises a N-terminal flexible domain and a C-terminal carbohydrate-recognition domain (CRD). It is mapped to human chromosome 14q22.3. Galectin-3 is expressed in sensory neurons, immune endothelial and epithelial cells.

Application

Galectin-3 human has been used:
  • to test its interaction with N-acetyl lactosamine coated onto quantum dots
  • to optimize Gal3-induced hemagglutination measurements in non-agglutinated or agglutinated chicken red blood cells (RBCs)
  • in Gal-3 binding assay of serum samples from multiple sclerosis patients

Biochem/physiol Actions

Galectin-3 (Gal3) has anti-apoptotic property and mediates adhesion of cancer cells to endothelium. The activity of Gal3 is inhibited by lactose. High levels of Gal3 is associated with cardiovascular disease and is a potential biomarker in fibrosis and inflammation associated with heart failure. Gal3 is involved in variety of biological events from differentiation to host defense and immunomodulation. Gal3 gene deletion is correlated to renal function anomalies like nephropathy. It is implicated in the pathogenesis of retinopathy and non-alcoholic fatty liver disease (NAFLD).
Galectin-3 has been associated with the inhibition of apoptosis and the progression of cancer, as well as being a mediator of inflammation. Studies have found a positive correlation between the expression of galectin-3 and tumorigenicity and metastasis in colon, liver, and thyroid cancer.

Physical form

The product is lyophilized from water with 2 μg of lactose as stabilizer per μg of galectin-3.

Other Notes

Galectin-3 is a member of the family of animal lectins, which selectively binds β-galactoside residues.

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AB10541MABT51SAB4501746
description

recombinant, expressed in E. coli, lyophilized powder

description

from rabbit, purified by affinity chromatography

description

clone M3/38, from rat

description

affinity isolated antibody

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

form

lyophilized powder

form

-

form

-

form

buffered aqueous solution

UniProt accession no.

P17931

UniProt accession no.

P17931

UniProt accession no.

P16110

UniProt accession no.

P17931

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

Gene Information

human ... LGALS3(3958)

Gene Information

human ... LGALS3(3958)

Gene Information

human ... LGALS3(3958)

Gene Information

human ... LGALS3(3958)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100


Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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