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Guanosine 5′-triphosphate lithium salt

Name: Guanosine 5&#8242;-triphosphate lithium salt
Brand: SIGMA
Price: 89 USD
Availability: InStock

~95% (HPLC), G protein activator, powder

Synonym(s):

GTP lithium salt

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Size/SKU	Availability	Price
25 mg	Check Cart for Availability	$89.00
100 mg	Check Cart for Availability	$283.00
500 mg	Check Cart for Availability	$909.00

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₅O₁₄P₃ · xLi⁺

CAS Number:

85737-04-8

Molecular Weight:

523.18 (free acid basis)

UNSPSC Code:

41106305

PubChem Substance ID:

24895236

NACRES:

NA.77

MDL number:

MFCD00070012

Assay:

~95% (HPLC)

Form:

powder

$89.00

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Properties

Product Name

Guanosine 5′-triphosphate lithium salt, ~95% (HPLC), powder

assay

~95% (HPLC)

Quality Segment

200

form

powder

color

white

solubility

H₂O: 100 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

WDCLDKGIVWUKSE-GWTDSMLYSA-M

Description

Application

Guanosine 5′-triphosphate lithium salt has been used:

In ribosome activity assay.
In tubulin isolation and polymerization.
In the determination of cell viability.

Biochem/physiol Actions

GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades.

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Guanosine 5′-triphosphate serves as a substrate for guanosine 5′-triphosphate 3′ diphosphate diphosphatase, a hydrolyzing enzyme and guanosine triphosphate guanyltransferase.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

Disclaimer

Stability is much better than sodium salt.

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This Item	G8877	G7637	A2647
Sigma-Aldrich G5884 Guanosine 5′-triphosphate lithium salt	Sigma-Aldrich G8877 Guanosine 5′-triphosphate sodium salt hydrate	Sigma-Aldrich G7637 Guanosine 5′-[β-thio]diphosphate trilithium salt	Sigma-Aldrich A2647 Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate
description ~95% (HPLC), powder	description ≥95% (HPLC), powder	description ≥85% (HPLC), powder	description ≥93% (HPLC), powder
form powder	form powder	form powder	form powder
assay ~95% (HPLC)	assay ≥95% (HPLC)	assay ≥85% (HPLC)	assay ≥93% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 100 mg/mL	solubility H₂O: 50 mg/mL	solubility H₂O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)	solubility H₂O: 50 mg/mL
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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