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G6642

Anti-Glutamate antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-Glutamate Ab, Glutamate Detection Antibody, Rabbit Anti-Glutamate

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Size/SKUAvailabilityPrice
0.2 mL

Estimated to ship onOctober 05, 2026fromMILWAUKEE

$620.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00162331
Conjugate:
unconjugated
Clone:
polyclonal
Application:
DB
Citations:
54

$620.00

Estimated to ship onOctober 05, 2026Details

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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

wide range

technique(s)

dot blot: 1:15,000

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

The amino acids L-glutamate (Glu) and L-aspartate (Asp) are considered the major excitatory neurotransmitters in the central nervous system (CNS) and represent the most abundant mammalian neurotransmitter class. Both L-glutamate and L-aspartate are present in the brain at high concentrations and are distributed in most excitatory pathways in the CNS. Glu- and Asp-immunoreactivities are localized in high concentrations in synaptic terminals. In nerve terminals, L-glutamate is formed by deamidation of its major precursor, L-glutamine, by the enzyme glutaminase.
The actions of the excitatory amino acids on neurons are mediated by different receptor subtypes. These receptors are coupled to integral ion channels or to a second messenger system which utilizes inositol triphosphate (IP3). L-glutamate and L-aspartate may play an important role in the pathogenesis of certain neurological disorders such as Huntington′s disease, Alzheimer′s disease, epilepsy and brain ischemia. The excitoxic and neurotoxic effects of L-glutamate, leading to extensive neuronal damage, appear to be mediated by the N-methyl-D-aspartate (NMDA) receptor subtype.

Immunogen

L-glutamic acid (Glu).

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit polyclonal antiserum to L-glutamate may be used in immunohistochemical techniques on formalin- or glutaraldehyde-fixed, vibratome or frozen sections of human or animal tissues. Immunohistochemical methods provide increased anatomical resolution over conventional biochemical methods.

Biochem/physiol Actions

The antiserum is evaluated for activity and specificity by dot-blot immunoassay. The antiserum recognizes L-glutamic acid immobilized on an affinity membrane. No cross-reaction is observed with L-aspartic acid, L-glutamine, L-asparagine, and L-alanine. Weak cross-reactivity is observed with Gly-Asp, GABA, β-alanine, glycine and 5-aminovaleric acid (amino acid concentration 5-10 mM). Weak to moderate reaction is observed with L-glutamic acid-containing dipeptides Asp-Glu and Gly-Glu. The antibody may be used to localize glutamate in cell bodies, axons, and terminals of glutamatergic neurons in the CNS.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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description

whole antiserum

description

from rabbit, purified by affinity chromatography

description

clone G6, from mouse

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

antibody form

whole antiserum

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

G6, monoclonal

clone

polyclonal

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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