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G8877

Guanosine 5′-triphosphate sodium salt hydrate

≥95% (HPLC), RNA synthesis substrate, powder

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Synonym(s):

GTP

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10 mg

Estimated to ship TODAYfromSAINT LOUIS

$41.70
25 mg

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$72.30
100 mg

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$170.00
250 mg

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$285.00
1 g

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$806.00

About This Item

Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+
CAS Number:
36051-31-7
Molecular Weight:
523.18 (free acid basis)
NACRES:
NA.77
PubChem Substance ID:
24895354
UNSPSC Code:
41106305
EC Number:
252-847-2
MDL number:
MFCD00077781
Beilstein/REAXYS Number:
3585677
Assay:
≥95% (HPLC)
Form:
powder

$41.70

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Product Name

Guanosine 5′-triphosphate sodium salt hydrate, ≥95% (HPLC), powder

Quality Segment

200

assay

≥95% (HPLC)

form

powder

color

white

solubility

H2O: 50 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

KZRMTEVIDYXWQW-CYCLDIHTSA-K

Gene Information

human ... HRAS(3265)

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:
  • in the preparation of horseradish peroxidase (HRP)-modified platination reagents
  • in whole cell, voltage-clamp recordings
  • in in vitro inhibition of transglutaminase (tTG)

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
Guanosine-5′-triphosphate is a purine nucleotide that acts as a substrate for the synthesis of RNA during the transcription. GTP is a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. Activates the signal transducing G proteins involved in proliferation, differentiation, and activation of several intracellular kinase cascades.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

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This Item
G3776G6129G7504
Guanosine 5′-triphosphate sodium salt hydrate ≥95% (HPLC), powder

Sigma-Aldrich

G8877

Guanosine 5′-triphosphate sodium salt hydrate

Guanosine 5′-triphosphate sodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription

Sigma-Aldrich

G3776

Guanosine 5′-triphosphate sodium salt solution

Guanosine 3′,5′-cyclic monophosphate sodium salt ≥99% (HPLC), powder

Sigma-Aldrich

G6129

Guanosine 3′,5′-cyclic monophosphate sodium salt

Guanosine 3′,5′-cyclic monophosphate ≥98% (HPLC), powder

Sigma-Aldrich

G7504

Guanosine 3′,5′-cyclic monophosphate

description

≥95% (HPLC), powder

description

HPLC purified, aqueous solution for RNA polymerase transcription

description

≥99% (HPLC), powder

description

≥98% (HPLC), powder

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥99% (HPLC)

assay

≥98% (HPLC)

form

powder

form

liquid

form

powder

form

powder

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: 50 mg/mL

solubility

-

solubility

H2O: 50 mg/mL

solubility

0.2 M NaHCO3: 50 mg/mL

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

-

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000587961
    0000587958
    0000587957
    0000587962
    0000587959

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    Questions

    1. Can assistance be provided in sourcing ATP and GTP for establishing an in vitro translation system from plant cells?

      1 answer

      1. Upon verification, there is currently no validated ATP or GTP product for in vitro translation application available. However, according to the following publication, ATP (cat#A2383) and GTP (cat#G8877) seem to work well for in vitro transcription and translation systems.

        Reference: Polyvinylsulfonic acid: A Low-cost RNase inhibitor for enhanced RNA preservation and cell-free protein translation

        Bioengineered. 2018 Jan 1;9(1):90-97. doi: 10.1080/21655979.2017.1313648. Epub 2017 Jun 29.PMID: 28662363

        Helpful?

    Reviews

    Active Filters

      • Reviews 2
      • Vote 1
      5 out of 5 stars.

      It is a high quality product and can be use for research purposes.

      Excellent product and I use it to measure GTPase activity.

      Helpful?