Key Documents

Guanosine 5′-triphosphate sodium salt hydrate

Name: Guanosine 5&#8242;-triphosphate sodium salt hydrate
Brand: SIGMA
Price: 43.2 USD
Availability: InStock

≥95% (HPLC), RNA synthesis substrate, powder

Synonym(s):

GTP

Select a Size

Change View

Size/SKU	Availability	Price
10 mg	Estimated to ship TODAYfromSAINT LOUIS	$43.20
25 mg	Estimated to ship TODAYfromSAINT LOUIS	$72.30
100 mg	Estimated to ship TODAYfromSAINT LOUIS	$170.00
250 mg	Estimated to ship TODAYfromSAINT LOUIS	$285.00
1 g	Estimated to ship TODAYfromSAINT LOUIS	$806.00

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₅O₁₄P₃ · xNa⁺

CAS Number:

36051-31-7

Molecular Weight:

523.18 (free acid basis)

NACRES:

NA.77

PubChem Substance ID:

24895354

UNSPSC Code:

41106305

EC Number:

252-847-2

MDL number:

MFCD00077781

Beilstein/REAXYS Number:

3585677

Assay:

≥95% (HPLC)

Form:

powder

$43.20

Estimated to ship TODAYDetails

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Guanosine 5′-triphosphate sodium salt hydrate, ≥95% (HPLC), powder

Quality Segment

200

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: 50 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

KZRMTEVIDYXWQW-CYCLDIHTSA-K

Gene Information

human ... HRAS(3265)

Description

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:

in the preparation of horseradish peroxidase (HRP)-modified platination reagents
in whole cell, voltage-clamp recordings
in in vitro inhibition of transglutaminase (tTG)

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Guanosine-5′-triphosphate is a purine nucleotide that acts as a substrate for the synthesis of RNA during the transcription. GTP is a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. Activates the signal transducing G proteins involved in proliferation, differentiation, and activation of several intracellular kinase cascades.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	G3776	51120	G5884
Sigma-Aldrich G8877 Guanosine 5′-triphosphate sodium salt hydrate	Sigma-Aldrich G3776 Guanosine 5′-triphosphate sodium salt solution	Sigma-Aldrich 51120 Guanosine 5′-triphosphate sodium salt hydrate	Sigma-Aldrich G5884 Guanosine 5′-triphosphate lithium salt
description ≥95% (HPLC), powder	description HPLC purified, aqueous solution for RNA polymerase transcription	description ≥90% (HPLC)	description ~95% (HPLC), powder
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥90% (HPLC)	assay ~95% (HPLC)
form powder	form liquid	form powder	form powder
Quality Level 200	Quality Level 300	Quality Level 100	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 50 mg/mL	solubility -	solubility water: 50 mg/mL, clear, colorless	solubility H₂O: 100 mg/mL
color white	color colorless	color -	color white

Still not finding the right product?

Explore all of our products under Guanosine 5′-triphosphate sodium salt hydrate

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Anonymous

2 years ago

Can assistance be provided in sourcing ATP and GTP for establishing an in vitro translation system from plant cells?

1 answer
1. Technical Support
  
  2 years ago
  
  Upon verification, there is currently no validated ATP or GTP product for in vitro translation application available. However, according to the following publication, ATP (cat#A2383) and GTP (cat#G8877) seem to work well for in vitro transcription and translation systems.
  Reference: Polyvinylsulfonic acid: A Low-cost RNase inhibitor for enhanced RNA preservation and cell-free protein translation
  Bioengineered. 2018 Jan 1;9(1):90-97. doi: 10.1080/21655979.2017.1313648. Epub 2017 Jun 29.PMID: 28662363
  
  Helpful?

Reviews

Rating Snapshot

Select a row below to filter reviews.

Average Customer Ratings

Overall, average rating value is 5 of 5.

Active Filters

Anonymous
Anonymous
Reviews 2

Vote 1
5 out of 5 stars.

Anonymous

4 years ago

It is a high quality product and can be use for research purposes.

Excellent product and I use it to measure GTPase activity.

Helpful?