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G8903

Ghrelin rat

lyophilized powder

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0.1 mg

Available to ship TODAYfromMILWAUKEE

$770.00
$654.50

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:

$654.50

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form

lyophilized powder

Quality Segment

color

white

solubility

1% acetic acid: 1 mg/mL, water: 1 mg/mL

UniProt accession no.

storage temp.

−20°C

Gene Information

rat ... Ghrl(59301)

General description

Ghrelin is a gut-brain orexigenic peptide that functions in hunger signaling. This peptide is prominently synthesized by stomach and transported to brain. However, a specific subset of hypothalamic neurons also produces this peptide. It is expressed in gastrointestinal tract, hypothalamic arcuate nucleus, pituitary, kidney, liver, heart, lung and adipose tissue This peptide is composed of 28 amino acids, and its Ser3 residue is N-octanoylated.

Application

Ghrelin rat has been used for intraperitoneal injections, and microinjections in rats to study its effects on celiac disease, and passive avoidance learning (PAV) and spatial learning, respectively. It has also been used for intracerebroventricular injection in rats to study its influence on penicillin-induced epileptiform activity in rat.

Biochem/physiol Actions

Ghrelin acts as a ligand for G-protein coupled receptor, GHS-R1A (growth hormone secretagogue receptor), and controls energy utilization and feeding. This peptide is involved in enhancing the value of rewarding foods, drugs and alcohol. In rats with diabetes, the expression of ghrelin increased as a result of cachexia. In rats with ovariectomy, the expression of this peptide decreased in the endometrium. This peptide controls cognitive functions and has neuroprotective roles in neurodegenerative disorders. In cultured cortical neuronal networks, ghrelin increases the rate of synapse formation and activity development.
Endogenous ligand to the orphan growth-hormone secretagogue receptor that stimulates the release of growth hormone from the pituitary.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

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This Item
N2513A4538494126
description

lyophilized powder

description

recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture

description

lyophilized powder, essentially globulin free, ≥99% (agarose gel electrophoresis)

description

The 28-amino acid n-octanoylated (at ser3) natural peptidyl ligand for the growth hormone secretagogue receptor 1a (GHSR1a).

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

solid

UniProt accession no.

Q9QYH7

UniProt accession no.

P25427

UniProt accession no.

P02770

UniProt accession no.

-

Gene Information

rat ... Ghrl(59301)

Gene Information

rat ... NGF(4803)

Gene Information

rat ... ALB(24186)

Gene Information

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

color

white

color

-

color

-

color

white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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