G9282
Monoclonal Anti-Glutamate antibody produced in mouse
clone GLU-4, ascites fluid
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| Size/SKU | Availability | Price |
|---|---|---|
0.2 mL | Check Cart for Availability | $602.00 |
About This Item
Conjugate:
unconjugated
Clone:
GLU-4, monoclonal
Application:
ELISA (i)
Citations:
17
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
GLU-4, monoclonal
contains
15 mM sodium azide
species reactivity
wide range
technique(s)
indirect ELISA: 1:10,000 using in situ prepared L-glutamate-glutaraldehyde-BSA conjugate for coating
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRM1(2911)
Immunogen
L-glutamic acid (Glu).
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immuno-electron microscopy (1 paper)
Immuno-electron microscopy (1 paper)
Monoclonal Anti-Glutamate antibody produced in mouse is suitable for:
- immunolabeling of glutamate in the lamina of the Drosophila visual system
- immunocytochemistry at a working dilution of 1:20,000 to detect glutamate using heart and extrinsic nerves of stomatopod crustacean, Squilla oratoria
- immunofluorescent staining as a primary antibody at a working dilution of 1:1000 using cryosections of brains and embryos from mice
- use as a primary antibody to measure the glutamate release in synaptosome preparations
Biochem/physiol Actions
Glutamate is an amino acid that acts as a excitatory neurotransmitter in the vertebrate brain and functions in all brain processes. It is released from one end of the neuron and it binds to receptors on the surface of adjacent neurons. Glutamate is released in a calcium-dependent manner in response to depolarizing stimuli. It serves as a substrate in certain metabolic pathways, such as, synthesis of glutamine and γ-aminobutyric acid (GABA) Excessive release of glutamate or aspartate have been observed in the pathogenesis of certain neurodegenerative diseases, such as, Huntington′s disease, Alzheimer′s disease. The same is also observed in selective neuronal degenerations involved in epilepsy, ischemia, and hypoglycemia.
The antibody reacts specifically with L-glutamate (L-glutamic acid), when immobilized with glutaraldehyde. Cross-reaction is observed with Gly-Glu and Asp-Glu. When using the product at the recommended working dilution, in indirect and competitive ELISA, weak cross-reaction may be obtained with D-glutamate, L-glutamine, L-aspartate, D-aspartate, L-asparagine, β-alanine, glycine, 5-aminovaleric acid, γ-aminobutyric acid (GABA) and Gly-Asp. Glutamate is found in cell bodies, axons, and terminals of glutamatergic neurons in the CNS.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| description clone GLU-4, ascites fluid | description clone GT-34, ascites fluid | description clone GB-69, ascites fluid | description clone FL-D6, ascites fluid |
| antibody form ascites fluid | antibody form ascites fluid | antibody form ascites fluid | antibody form ascites fluid |
| Gene Information human ... GRM1(2911) | Gene Information - | Gene Information mouse ... Gabra1(14394) | Gene Information - |
| clone GLU-4, monoclonal | clone GT-34, monoclonal | clone GB-69, monoclonal | clone FL-D6, monoclonal |
| species reactivity wide range | species reactivity sheep, goat, bovine | species reactivity wide range | species reactivity - |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
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Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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