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H125

(2-Hydroxypropyl)-γ-cyclodextrin

solid

Synonym(s):

HGC

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Size/SKUAvailabilityPrice
5 g

Available to ship TODAYfromMILWAUKEE

$159.00
100 g

Available to ship TODAYfromMILWAUKEE

$1,160.00

About This Item

CAS Number:
UNSPSC Code:
12352201
NACRES:
NA.77

$159.00


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form

solid

Quality Segment

concentration

1.000 mg/mL±0.005

technique(s)

cell culture | mammalian: suitable

color

white

solubility

H2O: 450 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

O1[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@H]([C@H](O[C@@H]4O[C@H]([C@H](O[C@@H]5O[C@H]([C@H](O[C@@H]6O[C@H]([C@H](O[C@@H]7O[C@H]([C@H](O[C@@H]8O[C@H]([C@H]1[C@H]([C@@H]8O)O)COCC(O)C)[C@H]([C@@H]7O)O)CO)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)CO)[C@H]([C@@H]4O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

Application

(2-Hydroxypropyl)-γ-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CCs) from plasma samples.

Biochem/physiol Actions

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation.

Other Notes

Non-toxic solubilizer. γ-Cyclodextrin (8-glucose units) has a slightly larger cavity and can accommodate larger substrates than β-cyclodextrin.

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H0396C4680H0888
description

solid

description

BioReagent, suitable for cell culture

description

powder, BioReagent, suitable for cell culture, ≥98%

description

BioReagent, suitable for cell culture

form

solid

form

crystalline

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

solubility

H2O: 450 mg/mL

solubility

H2O: 400 mg/mL

solubility

H2O: 10 mg/mL

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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