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H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

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Size/SKUAvailabilityPrice
0.1 mg
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$362.00
1 mg
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$1,220.00

About This Item

Empirical Formula (Hill Notation):
C30H42N2O9
CAS Number:
Molecular Weight:
574.66
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4834067
Assay:
≥95% (HPLC)
Form:
powder

$362.00


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biological source

Streptomyces hygroscopicus

Quality Segment

assay

≥95% (HPLC)

form

powder

color

yellow

solubility

DMSO: 7.5 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChI key

MCAHMSDENAOJFZ-BVXDHVRPSA-N

General description

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.
DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.
An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Disclaimer

Hygroscopic and photosensitive

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H5527H0654H7772
description

≥95% (HPLC), powder

description

≥60% (HPLC), 45-60 mg/mL in H2O, γ-irradiated

description

≥60% (HPLC), 45-60 mg/mL in H2O

description

lyophilized powder

form

powder

form

-

form

-

form

lyophilized powder

assay

≥95% (HPLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 7.5 mg/mL

solubility

-

solubility

-

solubility

H2O: 50 mg/mL

color

yellow

color

yellow-brown to orange

color

brown-yellow, light orange to dark orange, light yellow to dark yellow

color

faintly brown to brown, white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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