Skip to Content
MilliporeSigma

Skip To

H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
0.1 mg

Available to ship TODAYfromMILWAUKEE

$349.00
1 mg

Available to ship TODAYfromMILWAUKEE

$1,180.00
$1,003.00

About This Item

Empirical Formula (Hill Notation):
C30H42N2O9
CAS Number:
Molecular Weight:
574.66
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4834067
Assay:
≥95% (HPLC)
Form:
powder

$349.00


Available to ship TODAYDetails


Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


biological source

Streptomyces hygroscopicus

Quality Segment

assay

≥95% (HPLC)

form

powder

color

yellow

solubility

DMSO: 7.5 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChI key

MCAHMSDENAOJFZ-BVXDHVRPSA-N

General description

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.
DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.
An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Disclaimer

Hygroscopic and photosensitive

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
H9773H7772G3381
description

≥95% (HPLC), powder

description

suitable for plant cell culture, BioReagent, ≥60% (HPLC), lyophilized powder

description

lyophilized powder

description

≥98% (HPLC), powder

assay

≥95% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

powder

form

lyophilized powder

form

lyophilized powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 7.5 mg/mL

solubility

ethanol: soluble, methanol: soluble, H2O: soluble 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

DMSO: soluble

color

yellow

color

faintly brown to brown, white to beige

color

faintly brown to brown, white to beige

color

yellow to orange


Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters