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Indatraline hydrochloride

Name: Indatraline hydrochloride
Brand: SIGMA
Price: 201 USD
Availability: InStock

monoamine transport inhibitor, solid

Synonym(s):

(±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride, Lu 19-005

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Size/SKU	Availability	Price
10 mg	Check Cart for Availability	$201.00
25 mg	Check Cart for Availability	$419.00
100 mg	Check Cart for Availability	$1,410.00 $1,198.50

About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅Cl₂N · HCl

CAS Number:

96850-13-4

Molecular Weight:

328.66

UNSPSC Code:

12352200

PubChem Substance ID:

24277939

NACRES:

NA.77

MDL number:

MFCD00083178

Form:

solid

$201.00

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Properties

Product Name

Indatraline hydrochloride, solid

form

solid

Quality Segment

100

color

white

solubility

H₂O: 2 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13

InChI

1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1

InChI key

QICQDZXGZOVTEF-MELYUZJYSA-N

Gene Information

Description

Application

Indatraline hydrochloride has been used:

as a competitive inhibitor of 3H-dopamine ([³H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

Biochem/physiol Actions

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with the permission of H. Lundbeck A/S.

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This Item	289027
Sigma-Aldrich I119 Indatraline hydrochloride	Sigma-Aldrich 289027 3-Phenylbutyraldehyde
description solid	description 97%
form solid	form liquid
Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -
solubility H₂O: 2 mg/mL	solubility -
color white	color -
Gene Information human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)	Gene Information -

Pictograms

GHS09

Signal Word

Warning

Hazard Codes

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Gloves

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