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Anti-Human IgG (Fc specific), F(ab′)₂fragment antibody produced in goat

Name: Anti-Human IgG (Fc specific), F(ab′)<SUB>2 </SUB>fragment antibody produced in goat
Brand: SIGMA
Price: 541.45 CAD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Goat anti-human IgG

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Size/SKU	Availability	Price
1 mL	Please contact Customer Service for Availability	$637.00 $541.45

About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00162436

Conjugate:

unconjugated

Clone:

polyclonal

Application:

—

Citations:

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Properties

biological source

goat

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

buffered aqueous solution

concentration

2.0 mg/mL protein

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Description

General description

IgG antibody plays a crucial role in humoral immune responses such as phagocytosis, complement activation, placental transport and cell surface-receptor binding. Anti-human IgG (Fc specific), F(ab′)₂ fragment antibody can be used as a capture antibody in antibody-binding assay for soluble ICAM-1-Fc. Goat anti-human-IgG (Fc specific) F(ab′)₂ antibody reacts specifically with human IgG but does not react with other immunoglobulins.

IgG is the main type of antibody in human serum, secreted by the B cells. It consists of four polypeptide chains, made of two identical 50 kDa γ heavy (H) chains and two identical 25 kDa κ or λ light (L) chains, which are linked by inter-chain disulfide bonds. IgG contains four isotypes IgG1, IgG2, IgG3 and IgG4.

Immunogen

Purified human IgG

Application

Anti-human IgG (Fc specific), F(ab′)₂ fragment antibody can be used in ELISA to determine human IgG1-Fc protein.

Anti-Human IgG (Fc specific), F(ab′)₂ fragment antibody produced in goat has been used in studying the antibody binding assay of soluble intercellular adhesion molecule-1 (ICAM-1)-Fc.

Biochem/physiol Actions

IgG stimulates the classical pathway of the complement system. It neutralizes virus particles and toxins. IgG plays a crucial role in antibody-dependent cell-mediated cytotoxicity (ADCC). IgG might be associated with allergy. It has the longest serum half life.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.05% sodium azide

Preparation Note

Adsorbed to reduce background with mouse or rat samples.
Useful when trying to avoid background staining due to the presence of Fc receptors.

Other Notes

Antibody adsorbed with mouse and rat IgG

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB3701027	SAB3701279	SAB3700849
Sigma-Aldrich I3391 Anti-Human IgG (Fc specific), F(ab′)₂fragment antibody produced in goat	Sigma-Aldrich SAB3701027 Anti-Mouse IgG (Fc specific), F(ab′)₂ fragment, highly cross adsorbed antibody produced in goat	Sigma-Aldrich SAB3701279 Anti-Human IgG (Fc specific), highly cross adsorbed-Biotin antibody produced in goat	Sigma-Aldrich SAB3700849 Anti-Rabbit IgG (Fc specific), highly cross adsorbed antibody produced in goat
description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, buffered aqueous solution
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source goat	biological source goat	biological source goat	biological source goat
conjugate unconjugated	conjugate unconjugated	conjugate biotin conjugate	conjugate unconjugated
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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