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Interferon-γ-Inducible Protein-10 human

Name: Interferon-γ-Inducible Protein-10 human
Brand: SIGMA
Price: 222.7 USD
Availability: InStock

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

CXCL10, IP-10

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Size/SKU	Availability	Price
10 μg	Check Cart for Availability	$262.00 $222.70

About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD00241912

$222.70

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Properties

biological source

human

Quality Segment

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.015-0.075 μg/mL ED₅₀ (chemoattract mouse BaF3 cells transfected with hCXCR3), 0.03-0.18 μg/mL ED₅₀ (chemoattract T-Lymphocytes)

mol wt

8.7 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

P01579

storage temp.

−20°C

Gene Information

human ... CXCL10(3627)

Description

General description

The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

Biochem/physiol Actions

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.

IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

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This Item	I5528	I17001	SRP3312
Sigma-Aldrich I3400 Interferon-γ-Inducible Protein-10 human	Sigma-Aldrich I5528 Interferon-Inducible T Cell α Chemoattractant human	Sigma-Aldrich I17001 Interferon-γ human	Sigma-Aldrich SRP3312 IL-10 human
description ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder	description ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description IFN-gamma, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in E. coli
biological source human	biological source human	biological source -	biological source human
assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level -
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized
impurities endotoxin, tested	impurities <0.1ng/mg	impurities -	impurities endotoxin, tested

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Key Documents

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Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Select a Size

About This Item

$222.70

biological source

Quality Segment

recombinant

assay

form

potency

mol wt

packaging

impurities

UniProt accession no.

storage temp.

Gene Information

General description

Biochem/physiol Actions

Physical form

Analysis Note

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

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Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Select a Size

About This Item

I3400-10UG

$222.70

biological source

Quality Segment

recombinant

assay

form

potency

mol wt

packaging

impurities

UniProt accession no.

storage temp.

Gene Information

General description

Biochem/physiol Actions

Physical form

Analysis Note

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

Reviews

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