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I5036

Isocitrate Dehydrogenase 1 (NADP+) human

recombinant, expressed in E. coli, lyophilized powder, ≥80 units/mg protein

Synonym(s):

IDH1, Isocitrate Dehydrogenase Cytoplasmic

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Size/SKUAvailabilityPrice
100 μg

Available to ship TODAYfromMILWAUKEE

$570.00

About This Item

CAS Number:
9028-48-2
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
1.1.1.42 (BRENDA, IUBMB)
Specific activity:
≥80 units/mg protein
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli

$570.00

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recombinant

expressed in E. coli

Quality Segment

assay

≥90% (SDS-PAGE)

form

lyophilized powder

specific activity

≥80 units/mg protein

mol wt

46,658 Da

storage temp.

−20°C

General description

Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence.

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production.

Physical form

Supplied as a lyophilized powder containing Tris-HCl pH 8.0, trehalose, ammonium sulfate and DTT

Other Notes

One unit corresponds to the amount of enzyme which converts 1.0 μmol DL-isocitrate to α-ketoglutarate per minute at pH 7.4 and 37 °C (NADP as cofactor).

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I2411MABC1103HPA035248
Isocitrate Dehydrogenase 1 (NADP+) human recombinant, expressed in E. coli, lyophilized powder, ≥80 units/mg protein

Sigma-Aldrich

I5036

Isocitrate Dehydrogenase 1 (NADP+) human

Isocitrate Dehydrogenase 1 (NADP+) human recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)

Sigma-Aldrich

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Isocitrate Dehydrogenase 1 (NADP+) human

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Sigma-Aldrich

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Anti-IDH1 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA035248

Anti-IDH1 antibody produced in rabbit

description

recombinant, expressed in E. coli, lyophilized powder, ≥80 units/mg protein

description

recombinant, expressed in Sf9 cells, ≥90% (SDS-PAGE)

description

clone MsMAb-1, from mouse

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

specific activity

≥80 units/mg protein

specific activity

-

specific activity

-

specific activity

-

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

-

assay

-

recombinant

expressed in E. coli

recombinant

expressed in Sf9 cells

recombinant

-

recombinant

-

form

lyophilized powder

form

buffered aqueous glycerol solution

form

-

form

buffered aqueous glycerol solution

mol wt

46,658 Da

mol wt

47.6 kDa

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

−70°C

storage temp.

-

storage temp.

−20°C

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Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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