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Anti-Interleukin-12 antibody produced in goat

Name: Anti-Interleukin-12 antibody produced in goat
Brand: SIGMA
Price: 651 USD
Availability: InStock

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-IL-12

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Size/SKU	Availability	Price
1 mg	Available to ship TODAYfromMILWAUKEE	$651.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00212982

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Neutral

Citations:

$651.00

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Properties

biological source

goat

Quality Segment

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable

UniProt accession no.

P29459

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL12A(3592)

Description

General description

Interleukin-12 (IL-12) is an important cytokine that links innate and adaptive immunity. It plays a role in the regulation of Th1-associated cellular immunity to foreign pathogens, and humoral immunity to antigens that are both T cell-independent and T cell-dependent. IL-12 is primarily produced by innate immune cells, dendritic cells, epithelial cells and macrophages. All forms of IL-12 bind to the IL-12R which includes IL-12RbI and IL-12RbII subunits expressed on T cells and natural cells. IL-12 stimulates the production of IFN-γ and TNF-α, subsequent production of nitric oxide that leads to pathogen destruction. Reports suggest the involvement of JAK/STAT pathway components in mediating these effects. The effects of IL-12 have been implicated in bacterial, fungal and viral infections. Due to its role in inducing matrix metalloproteases, it also has important role in the etiology of chronic B-cell malignancies and lung adenocarcinomas
Anti-Interleukin-12 antibody recognizes human IL-12.

Immunogen

recombinant human IL-12 expressed in Sf 21 insect cells.

Application

Anti-Interleukin-12 antibody may be used for ELISA at a working antibody concentration of 0.5 μg/ml. For immunoblotting, a working concentration of 1 μg/ml is recommended. The antibody is also suitable for neutralization reactions.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human IL-12.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	I7642	I8273	I8909
$Anti-Interleukin-12 antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I5395 Anti-Interleukin-12 antibody produced in goat	$Anti-Interleukin-12 antibody produced in goat IgG fraction of antiserum$ Sigma-Aldrich I7642 Anti-Interleukin-12 antibody produced in goat	$Anti-Interleukin-2 antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8273 Anti-Interleukin-2 antibody produced in goat	$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8909 Anti-Interleukin-1α antibody produced in goat
description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum	description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum, lyophilized powder
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum
biological source goat	biological source goat	biological source goat	biological source goat
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
form lyophilized powder	form -	form lyophilized powder	form lyophilized powder
species reactivity human	species reactivity mouse	species reactivity human	species reactivity human

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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