I8250
3-Iodo-L-tyrosine
Tyrosine hydroxylase inhibitor
Synonym(s):
3-Monoiodo-L-tyrosine
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | $78.10 |
5 g | Check Cart for Availability | $284.00 |
25 g | Check Cart for Availability | $1,080.00 |
About This Item
Linear Formula:
IC6H3-4-(OH)CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
307.09
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352200
EC Number:
200-744-8
MDL number:
Beilstein/REAXYS Number:
2941266
Product Name
3-Iodo-L-tyrosine,
Quality Segment
impurities
~5% tyrosine
mp
210 °C (dec.) (lit.)
solubility
dilute aqueous acid: soluble
storage temp.
−20°C
SMILES string
N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
InChI
1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChI key
UQTZMGFTRHFAAM-ZETCQYMHSA-N
Gene Information
human ... TH(7054)
General description
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).
Application
3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.
Biochem/physiol Actions
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.
TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.
Tyrosine hydroxylase inhibitor.
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This Item | |||
|---|---|---|---|
| description - | description crystalline | description 97% | description 98% |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| impurities ~5% tyrosine | impurities - | impurities - | impurities - |
| storage temp. −20°C | storage temp. - | storage temp. - | storage temp. - |
| Gene Information human ... TH(7054) | Gene Information - | Gene Information - | Gene Information - |
| mp 210 °C (dec.) (lit.) | mp 233-235 °C (dec.) (lit.) | mp 249 °C (lit.) | mp 158-160 °C (dec.) (lit.) |
| solubility dilute aqueous acid: soluble | solubility - | solubility - | solubility - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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