Currently, the supplied Ivermectin products are in solid/powder form. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
I8898
Ivermectin
α7 neuronal nicotinic acetylcholine receptor modulator, powder
Synonym(s):
22,23-Dihydroavermectin B1, MK-933
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| Size/SKU | Availability | Price |
|---|---|---|
250 mg | Available to ship TODAYfromMILWAUKEE | $41.00 |
1 g | Available to ship TODAYfromMILWAUKEE | $121.00 |
About This Item
CAS Number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Product Name
Ivermectin,
form
powder
Quality Segment
solubility
MEK: 50 mg/mL
antibiotic activity spectrum
parasites
application(s)
agriculture
environmental
mode of action
cell membrane | interferes
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
storage temp.
2-8°C
SMILES string
[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
InChI
1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChI key
AZSNMRSAGSSBNP-XPNPUAGNSA-N
Gene Information
human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)
General description
Application
Ivermectin has been used:
- in Caenorhabditis elegans fecundity assay
- in larval development test
- to measure in vivo topical acaricide activity of compounds in rats
- to assess its acute and chronic effects to zebrafish
- in percutaneous drug injection method to treat cystic echinococcosis
- in liquid chromatography with fluorescence detection method
Biochem/physiol Actions
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Primarily ivermectin B1a.
1 of 1
This Item | |||
|---|---|---|---|
| description - | description European Pharmacopoeia (EP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material | description ≥98% (HPLC), powder |
| form powder | form - | form - | form powder |
| Quality Level 100 | Quality Level - | Quality Level 300 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility MEK: 50 mg/mL | solubility - | solubility - | solubility DMSO: ≥5 mg/mL |
| originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator - | originator - | originator Roche |
| application(s) agriculture | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Je suis à l recherche de cachets d ivermctine de 0,12mg
1 answer-
Helpful?
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Is product I8898, Ivermectin the analytical standard grade level? if not, what level is it?
1 answer-
This product is considered a research grade with an assigned quality level of 100. Other Ivermectin products available are primary or secondary pharmaceutical reference standards. Please see the link below to review additional information regarding product quality levels:
https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-programPlease see the following link to review alternative Ivermectin standard product options:
https://www.sigmaaldrich.com/search/ivermectin-standard?focus=products&page=1&perpage=30&sort=relevance&term=ivermectin%20standard&type=productHelpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solution stability of Ivermectin (Product No. I8898)?
1 answer-
Stock solutions of Ivermectin in DMSO at a concentration of 10 mM have been found to be stable for 2 weeks at -20°C, according to Shan, Q., et al., in Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel. J. Biol. Chem., 276(16), 12556-12564 (2001).
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the composition of the submoieties B1A and B1B in Product No. I8898, Ivermectin?
1 answer-
Unfortunately we do not test each lot to determine the composition. In the past, lots have been ~95% B1A and ~5% B1B; however there will be lot-to-lot variation.
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What is the molecular weight of Product No. I8898, Ivermectin?
1 answer-
This product is a mixture of two submoieties B1A, MW 891.1 and B1B, MW 877.1. It is typically predominantly B1A, so you may use a molecular weight of 890 in your calculations.
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