Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

I9154

Interleukin-10 from rat

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

IL-10

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 μg

Available to ship TODAYfromMILWAUKEE

$685.00
$582.25

About This Item

UNSPSC Code:
12352202
EC Number:
201-064-4
NACRES:
NA.32
MDL number:
MFCD01635777

$582.25

List Price$685.00Save 15%
Web-Only Promotion

Available to ship TODAYDetails

​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rat

Quality Segment

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

1-35 ng/mL ED50

mol wt

predicted mol wt ~19 kDa

packaging

pkg of 5 μg

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

rat ... Il10(25325)

Application

Interleukin-10 (IL-10) from rat has been used to study the anti-allodynic effect of IL-10 in rat model.

Biochem/physiol Actions

Interleukin-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions; blocks the activation of cytokine synthesis and several accessory functions of macrophages; enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion.

Physical form

Lyophilized from a 0.2 μm filtered in 20 mM Tris, 0.1 M sodium chloride containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured in a cell proliferation assay using the murine mast cell line, MC/9.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
I2276H7541I2393
Interleukin-10 from rat >95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Sigma-Aldrich

I9154

Interleukin-10 from rat

Interleukin-12 human ≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I2276

Interleukin-12 human

Interleukin-10 human IL-10, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Sigma-Aldrich

H7541

Interleukin-10 human

Interleukin-1β from rat IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I2393

Interleukin-1β from rat

description

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

description

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

description

IL-10, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

description

IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

rat

biological source

human

biological source

human

biological source

rat

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

assay

≥97% (SDS-PAGE and N-terminal analysis)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

WGK

WGK 3

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    061M1402
    035K1662
    MKCK8089
    069K1256
    108K1461

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Questions

    Reviews

    No rating value

    Active Filters